Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Eosinophilic Gastritis

  • Helena BaldaiaEmail author
Reference work entry


“Allergic” gastroenteritis; Eosinophilic gastroenteritis


Eosinophilic gastritis is characterized by a prominent eosinophil-rich inflammation in the gastric wall (Lash et al. 2009) without known cause. Isolated gastric eosinophilia is very rare and it is usually associated with involvement of the duodenum, esophagus, or other gastrointestinal (GI) segments, which is also referred as eosinophilic gastroenteritis (Lash et al. 2009).

As the gastric mucosa has a variable number of eosinophils, the diagnosis, especially in biopsy material, can be difficult. One study addressed the number of eosinophil counts in the normal gastric mucosa and other eosinophil-rich entities in the stomach and the authors proposed working diagnostic criteria: (1) patients who have gastric biopsies that show an average density of >127 eosinophils/mm2(or ≥30 eosinophils per HPF in microscopes equipped with wide-lens oculars) and (2) patients that have no known associated causes of...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). The nonneoplastic stomach. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 196–197). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  2. Holroyd, D. J., Banerjee, S., Chaudhary, K. S., et al. (2010). Transmural eosinophilic gastritis with gastric outlet obstruction: Case report and review of the literature. Annals of the Royal College of Surgeons of England, 92(4), W18–W20.CrossRefGoogle Scholar
  3. Lash, R. H., Lawuers, G. Y., Odze, R. D., & Genta, R. M. (2009). Inflammatory disorders of the stomach. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
  4. Lwin, T., Melton, S. D., & Genta, R. M. (2011). Eosinophilic gastritis: Histopathological characterization and quantification of the normal gastric eosinophil content. Modern Pathology, 24, 4,556–563.CrossRefGoogle Scholar
  5. Robert, M. E. (2009). Inflammatory disorders of the small intestine. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
  6. Rothenberg, M. E. (2004). Eosinophilic gastrointestinal disorders (EGID). The Journal of Allergy and Clinical Immunology, 113(1), 11–28.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaCentro Hospitalar de São JoãoPortoPortugal