Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Gastritis Cystica Polyposa/Profunda

  • Chella R. S. van der PostEmail author
  • Fátima Carneiro
Reference work entry


Gastritis cystica profunda; Gastritis cystica superficialis; Polypoid cystic gastritis; Stomal polypoid hypertrophic gastritis


Gastritis cystica polyposa is defined as a polypoid lesion or mass in the gastric wall, most often around a gastroenterostomy site, containing elongated gastric foveolae and cystically dilated glands extending into the muscularis mucosa and submucosa. In literature, similar findings are described under several synonymic terms. Gastritis cystica polyposa or profunda is the most commonly used name for this disorder. The lesion is better defined as “polyposa” when an intraluminal polyp is present and “profunda” when the bulk of the lesion is located in the wall of the stomach.

Gastritis cystica polyposa is considered to be a mucosal prolapsed condition caused by several factors, such as chronic inflammation, ischemia, presence of foreign material, and prior gastric surgery. Previous partial gastrectomy can lead to mucosal damage in the remnant...

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References and Further Reading

  1. Choi, M. G., Jeong, J. Y., Kim, K. M., Bae, J. M., Noh, J. H., Sohn, T. S., et al. (2012). Clinical significance of gastritis cystica profunda and its association with Epstein-Barr virus in gastric cancer. Cancer, 118(21), 5227–5233.PubMedGoogle Scholar
  2. Kurland, J., DuBois, S., Behling, C., & Savides, T. (2006). Severe upper-GI bleed caused by gastritis cystica profunda. Gastrointestinal Endoscopy, 63(4), 716–717.PubMedGoogle Scholar
  3. Littler, E. R., & Gleibermann, E. (1972). Gastritis cystica polyposa. (Gastric mucosal prolapse at gastroenterostomy site, with cystic and infiltrative epithelial hyperplasia). Cancer, 29(1), 205–209.PubMedGoogle Scholar
  4. Park, C. H., Park, J. M., Jung, C. K., Kim, D. B., Kang, S. H., Lee, S. W., et al. (2009). Early gastric cancer associated with gastritis cystica polyposa in the unoperated stomach treated by endoscopic submucosal dissection. Gastrointestinal Endoscopy, 69(6), e47–e50.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Chella R. S. van der Post
    • 1
    Email author
  • Fátima Carneiro
    • 2
  1. 1.Department of PathologyRadboud University Medical CenterNijmegenThe Netherlands
  2. 2.Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3SPortoPortugal