Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Lymphocytic Esophagitis

  • Paula Borralho NunesEmail author
Reference work entry


Lymphocytic esophagitis (LE) is defined as a histologic phenotype of esophagitis, which is characterized by an excess of intraepithelial lymphocytes (IELs) in the peripapillary fields, with spongiosis and no or only rare intraepithelial granulocytes. The patients present with chronic dysphagia, odynophagia, and motility disorders.

There have been conflicting studies on the true existence of lymphocytic esophagitis, a condition first described by Rubio et al. in 2006. Controversy still exists over whether LE is a true pathologic entity with a corresponding specific clinical correlate or whether LE is merely a nonspecific histologic finding, eventually representing an extreme in the spectrum of gastroesophageal reflux disease or an involvement in other inflammatory conditions (e.g., Crohn’s disease, celiac disease). In fact, in some cases of histologic diagnosis of LE, there is an associated Crohn’s disease, and this seems to be is a relatively common finding particularly in...

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References and Further Reading

  1. Cohen, S., Saxena, A., & Waljee, A. K. (2012). Lymphocytic esophagitis: A diagnosis of increasing frequency. Journal of Clinical Gastroenterology, 46(10), 828–832.CrossRefGoogle Scholar
  2. Ebach, D. R., Vanderheyden, A. D., Ellison, J. M., et al. (2011). Lymphocytic esophagitis: A possible manifestation of pediatric upper gastrointestinal Crohn’s disease. Inflammatory Bowel Diseases, 17(1), 45–49.CrossRefGoogle Scholar
  3. Haque, S., & Genta, R. M. (2012). Lymphocytic oesophagitis: Clinicopathological aspects of an emerging condition. Gut, 61(8), 1108–1114.CrossRefGoogle Scholar
  4. Purdy, J. K., Appelman, H. D., Golembeski, C. P., et al. (2008). Lymp hocytic esophagitis: A chronic or recurring pattern of esophagitis resembling allergic contact dermatitis. American Journal of Clinical Pathology, 130(4), 508–513.CrossRefGoogle Scholar
  5. Rubio, C. A., Sjödahl, K., & Lagergren, J. (2006). Lymphocytic esophagitis. A histologic subset of chronic esophagitis. American Journal of Clinical Pathology, 125(3), 432–437.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Hospital Cuf Descobertas and Escola Superior de Tecnologia da Saúde de Lisboa and Instituto de Anatomia Patológica, Faculdade de Medicina daUniversidade de LisboaLisboaPortugal