Eosinophilic (allergic, idiopathic) esophagitis; Primary eosinophilic esophagitis
Eosinophilic esophagitis has been described as a variant of the family of presumably allergic eosinophilic disorders that can involve any portion of the gastrointestinal tract (Antonioli and Furuta 2005). The favored interpretation is that it is the result from local hypersensitivity to food- or blood-borne allergens and that antigen-presenting cells play an important role in its pathogenesis (Lucendo et al. 2007). It is a recently recognized disorder that has some features that may mimic gastroesophageal reflux disease (GERD) clinically, endoscopically, and histologically. By definition, patients have normal pH monitoring levels and fail to respond to antireflux therapy. Eosinophilic esophagitis tends to occur in children or young adults, with a strong male predominance, and its pathogenesis is not fully understood. Many affected patients reveal an allergic history and have...
References and Further Reading
- Lucendo, A. J., Navarro, M., Comas, C., Pascual, J. M., Burgos, E., Santamaría, L., & Larrauri, J. (2007). Immunophenotypic characterization and quantification of the epithelial inflammatory infiltrate in eosinophilic esophagitis through stereology: an analysis of the cellular mechanisms of the disease and the immunologic capacity of the esophagus. The American Journal of Surgical Pathology, 31, 598–606.CrossRefGoogle Scholar