Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Epstein-Barr Virus (EBV), Esophagitis

  • Paula Borralho NunesEmail author
Reference work entry


Human herpesvirus four esophagitis


Epstein-Barr virus (EBV) esophagitis is a form of esophagitis caused by herpesvirus in immunocompetent or immunocompromised patients.

EBV is a ubiquitous virus that infects and establishes a persistent infection in the host. Clinically, it causes two types of infection: the primary infection, which ranges from a mild self-limited illness in children to infectious mononucleosis in adolescents and adults, and the reactivation of latent infection in immunocompromised patients (Gesser 1997). EBV replicates and is shed periodically from epithelial cells in the oropharynx or from salivary glands and persists through interactions with two different host cell types: epithelial cells at the surface of the body that are fully permissive for the production of infectious virus and serve to transmit the virus from person to person and cells situated deeper in the body that generally are nonpermissive and function as a reservoir of latent virus.

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Gesser, R. M. (1997). The role of latency in herpesvirus infections. Seminars in Pediatric Infectious Diseases, 8(3), 128–135.CrossRefGoogle Scholar
  2. Gulley, M. L. (2001). Molecular diagnosis of Epstein-Barr virus-related diseases. The Journal of Molecular Diagnostics, 3(1), 1–10.CrossRefGoogle Scholar
  3. Kitchen, V. S., Helbert, M., Francis, N. D., Logan, R. P. H., et al. (1990). Epstein-Barr virus associated oesophageal ulcers in AIDS. Gut, 31, 1223–1225.CrossRefGoogle Scholar
  4. Pape, M., Mandraveli, K., Sidiropoulos, I., et al. (2009). Unusual Epstein-Barr esophageal infection in an immunocompetent patient: A case report. Journal of Medical Case Reports, 3, 7314.CrossRefGoogle Scholar
  5. Pattengale, P. K., Smith, R. W., & Gerber, P. (1973). Selective transformation of B lymphocytes by EB virus. Lancet, ii, 93–94.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Hospital Cuf Descobertas and Escola Superior de Tecnologia da Saúde de Lisboa and Instituto de Anatomia PatológicaFaculdade de Medicina da, Universidade de LisboaLisboaPortugal