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Pathology of the Gastrointestinal Tract pp 544–547Cite as

Neuroendocrine Tumor, Gastric

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Mixed adenoneuroendocrine carcinomas (MANECs); Neuroendocrine carcinomas (NECs); Neuroendocrine tumors (NETs)

Definition

Neuroendocrine neoplasms of the digestive system (Rindi et al. 2010), namely, in the stomach (g-NENs), include (1) Neuroendocrine tumors (NETs) – carcinoids and well-differentiated endocrine tumors/carcinomas; (2) Neuroendocrine carcinomas (NECs): poorly differentiated endocrine carcinomas, high-grade neuroendocrine carcinomas, small-cell and large-cell endocrine carcinomas; and (3) Mixed adenoneuroendocrine carcinomas (MANECs) (Solcia et al. 2010); there are also hyperplastic and preneoplastic neuroendocrine lesions. Precursor neuroendocrine lesions of the stomach that occur in hypergastrinemic conditions (autoimmune chronic atrophic gastritis, multiple endocrine neoplasia type 1, and Zollinger-Ellison syndrome) include (a) enterochromaffin-like cell (ECL) hyperplasia (linear, micronodular <150 μm, and adenomatoid) and (b) dysplasia(enlarged micronodules...

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References and Further Reading

  • Fave, G. D., Kwekkeboom, D. K., Cutsem, E. V., Rindi, G., Kos-Kudla, B., Knigge, U., Sasano, H., Tomasseti, P., Salazar, R., Rusznieweski, P., & Barcelona Consensus Conference participants. (2012). ENETS consensus guidelines for the management of patients with gastroduodenal neoplasms. Neuroendocrinology, 95, 74–87.

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  • Rindi, G., Kloppel, G., Alhman, H., Caplin, M., Couvelard, A., de Herder, W. W., Erikssson, B., Falchetti, A., Falconi, M., Komminoth, P., Korner, M., Lopes, J. M., McNicol, A. M., Nilsson, O., Perren, A., Scarpa, A., Scoazec, J. Y., Wiedenmann, B., & Frascati Consensus Conference Participants. (2006). TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Archiv, 449, 395–401.

    Article  CAS  Google Scholar 

  • Rindi, G., Kloppel, G., Couvelard, A., Kommonoth, P., Korner, M., Lopes, J. M., NcNicol, A. M., Nilsson, O., Perren, A., Scarpa, A., Scoazec, J. Y., & Wiedenmann, B. (2007). TNM staging of midgut and hindgut (neuro) endocrine tumors: A consensus proposal including a grading system. Virchows Archiv, 451, 757–762.

    Article  CAS  Google Scholar 

  • Rindi, G., Arnold, R., Bosman, F. T., Capella, C., Klimstra, D. S., Kloppel, G., & Solcia, E. (2010). Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. E. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 13–14). Lyon: International Agency for Research on Cancer (IARC).

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  • Solcia, E., Arnold, R., Capella, C., Klimstra, D. S., Kloppel, G., Kominoth, P., & Rindi, G. (2010). Neuroendocrine neoplasms of Stomach. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. E. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 64–68). Lyon: International Agency for Research on Cancer (IARC).

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Author information

Authors and Affiliations

  1. Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias S/N, 4200-465, Porto, Portugal

    José Manuel Lopes

Authors
  1. José Manuel Lopes
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Correspondence to José Manuel Lopes .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Lopes, J.M. (2017). Neuroendocrine Tumor, Gastric. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1588

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1588

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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