Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Gastric Epithelial Dysplasia

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1585

Synonyms

Gastric intraepithelial neoplasia, adenoma.

Definition

Gastric epithelial dysplasia represents unequivocal gastric epithelial neoplastic proliferation characterized by variable cytological and architectural atypia, without convincing evidence of invasive growth.

Clinical Features

  • Incidence

    Incidence of gastric epithelial dysplasia shows considerable geographic differences and is usually associated with the regional prevalence of Helicobacter pylori infection. The incidence of dysplasia varies from 0.5% to 4% in western populations and from 9% to 20% in high-risk areas for gastric carcinomas.

  • Age

    The incidence of gastric epithelial dysplasia increases with age. It is much more prevalent after sixth decade.

  • Sex

    Gastric epithelial dysplasia is more frequent in males than in females, with a male to female ratio of 1.2–3:1.

  • Site

    Gastric epithelial dysplasia occurs more frequently in the gastric antrum and incisura angularis, although it can involve the whole stomach.

  • Treatment

    The...

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References and Further Reading

  1. de Vries, A. C., & Kuipers, E. J. (2007). Epidemiology of premalignant gastric lesions: Implications for the development of screening and surveillance strategies. Helicobacter, 12(Suppl 2), 22–31. Review. PubMed PMID: 17991173.PubMedCrossRefGoogle Scholar
  2. Dixon, M. F. (2002). Gastrointestinal epithelial neoplasia: Vienna revisited. Gut, 51(1), 130–131. PubMed PMID: 12077106; PubMed Central PMCID: PMC1773259.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Lauwers, G. Y., & Riddell, R. H. (1999). Gastric epithelial dysplasia. Gut, 45(5), 784–790. Review. PubMed PMID: 10517922; PubMed Central PMCID:PMC1727726.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Raftopoulos, S. C., Kumarasinghe, P., de Boer, B., Iacobelli, J., et al. (2012). Gastric intraepithelial neoplasia in a Western population. European Journal of Gastroenterology and Hepatology, 24(1), 48–54. PubMed PMID: 22081007.PubMedCrossRefGoogle Scholar
  5. You, W. C., Blot, W. J., Li, J. Y., Chang, Y. S., Jin, M. L., Kneller, R., Zhang, L., Han, Z. X., Zeng, X. R., & Liu, W. D. (1993). Precancerous gastric lesions in a population at high risk of stomach cancer. Cancer Research, 53(6), 1317–1321. PubMed Central PMCID:PMC1 8443811.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Centro hospitalar de Vila Nova de Gaia/EspinhoInstitute of Molecular Pathology and Immunology of the University of PortoPortoPortugal