Gastric Epithelial Dysplasia
Gastric intraepithelial neoplasia, adenoma.
Gastric epithelial dysplasia represents unequivocal gastric epithelial neoplastic proliferation characterized by variable cytological and architectural atypia, without convincing evidence of invasive growth.
Incidence of gastric epithelial dysplasia shows considerable geographic differences and is usually associated with the regional prevalence of Helicobacter pylori infection. The incidence of dysplasia varies from 0.5% to 4% in western populations and from 9% to 20% in high-risk areas for gastric carcinomas.
The incidence of gastric epithelial dysplasia increases with age. It is much more prevalent after sixth decade.
Gastric epithelial dysplasia is more frequent in males than in females, with a male to female ratio of 1.2–3:1.
Gastric epithelial dysplasia occurs more frequently in the gastric antrum and incisura angularis, although it can involve the whole stomach.