Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

C-Kit (CD117), Gastrointestinal Stromal Tumors (GISTs)

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1572

Synonyms

CD117; C-Kit synonyms include C-Kit; Mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; Proto-oncogene c-Kit; Proto-oncogene tyrosine-protein kinase Kit; SCFR; Soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Definition

C-Kit (CD117) is an antibody that identifies the C-Kit protein.

Molecule Type and Chemical Structure

C-Kit belongs to the type III receptor tyrosine kinase (RTK) subfamily, whose members include platelet-derived growth factor receptors α and β (PDGFRα and PDGFRβ) (Roskoski 2005). All type III RTKs contain five immunoglobulin-like domains in their extracellular ligand-binding region followed by a single transmembrane domain and a cytoplasmic tyrosine kinase domain interrupted by a large kinase insert. The ligand of KIT is known as stem cell factor. C-Kit(the gene) is transcribed and ultimately translated into the KIT protein, a transmembrane receptor tyrosine...

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References and Further Reading

  1. Corless, C. L., Barnett, C. M., & Heinrich, M. C. (2011). Gastrointestinal stromal tumours: Origin and molecular oncology. Nature Reviews Cancer, doi:10.1038/nr3143.PubMedGoogle Scholar
  2. Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Muhammad, T. G., Matsuzawa, Y., Kanakura, Y., Shinomura, Y., & Kitamura, Y. (1998). Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 279, 577–580.PubMedCrossRefGoogle Scholar
  3. Lennartsson, J., & Rönnstrand, L. (2006). The stem cell factor receptor/c-Kit as a drug target in cancer. Current Cancer Drug Targets, 6, 561–571.CrossRefGoogle Scholar
  4. Roskoski, R. (2005). Structure and regulation of Kit protein-tyrosine kinase – The stem cell factor receptor. Biochemical and Biophysical Research Communications, 338, 1307–1315.PubMedCrossRefGoogle Scholar
  5. Wong, N. A. C. S. (2011). Gastrointestinal stromal tumours – An update for histopathologists. Histopathology, 59, 807–821.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of PortoPortoPortugal