Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Choriocarcinoma, Gastrointestinal

  • Helena Baldaia
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1571

Synonyms

Cytotrophoblast; Germ cell tumor; Nongestational choriocarcinoma; Syncytiotrophoblast

Definition

Choriocarcinoma is an aggressive germ cell tumor that can rarely occur in extragonadal location (Iyomasa et al. 2003). In the gastrointestinal tract, the occurrence of pure choriocarcinoma is very rare, being more frequently diagnosed in association with adenocarcinoma (Fenoglio-Preiser et al. 2008a). In the esophagus, a few of the reported cases were coexistent with squamous cell carcinoma (Glickman and Odze 2009).

This type of tumor presents itself commonly as massive gastrointestinal (GI) bleeding, liver hemorrhage from metastatic disease, or abdominal pain (Kobayashi et al. 2005).

Choriocarcinoma is frequently associated with markedly elevated serum human chorionic gonadotropin (hCG) levels (Fenoglio-Preiser et al. 2008b).

Given the rarity of this type of tumor, before a diagnosis of primary GI choriocarcinoma can be made, it is important to exclude the possibility of an...

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References and Further Reading

  1. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008a). The noplastic stomach. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (p. 268). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  2. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008b). Epithelial tumors of the small intestine. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 486–487). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  3. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008c). Epithelial neoplasms of the colon. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 982–983). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  4. Glickman, J. N., & Odze, R. D. (2009). Epithelial neoplasms of the esophagus. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
  5. Harada, M., Inoue, T., & Hamano, K. (2012). Choriocarcinoma of the sigmoid colon: Report of a case. Surgery Today, 42(1), 93–96.PubMedCrossRefGoogle Scholar
  6. Iyomasa, S., Senda, Y., Mizuno, K., et al. (2003). Primary choriocarcinoma of the jejunum: Report of a case. Surgery Today, 33(12), 948–951.PubMedCrossRefGoogle Scholar
  7. Kobayashi, A., Hasebe, T., Endo, Y., et al. (2005). Primary gastric choriocarcinoma: Two case reports and a pooled analysis of 53 cases. Gastric Cancer, 8(3), 178–185.PubMedCrossRefGoogle Scholar
  8. Noffsinger, A. (2009). Epithelial neoplasms of the small intestine. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaCentro Hospitalar de São JoãoPortoPortugal