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Chagas Disease, Gastrointestinal Aspects

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  • First Online:
Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

American trypanosomiasis

Definition

Chagas disease is an important parasitic disease resulting from the infection with Trypanosoma cruzi (T. cruzi), a hemoflagellate protozoa whose vectors are triatomine insects, a type of reduviid bug known as the “barber bug.” It is one of the most serious public health problems in South America. The name was a tribute to its discoverer, the Brazilian medical doctor, scientist, and researcher Carlos Chagas (1879–1934). The achievement of Chagas, considered unique in the history of medicine, is a milestone in the history of Brazilian science and health (www.fiocruz.br/chagas).

In 1909, Carlos Chagas, from The Oswaldo Cruz Institute, announced the discovery of a new human disease. Chagas was the only researcher so far to completely describe a new infectious disease: its pathogen, vector (Triatominae), host, clinical manifestations, and epidemiology. The discovery brought immediate prestige and projection to the young scientist, who received...

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References and Further Reading

  • Andrade, Z. (2000). Patologia da doença de Chagas. In Z. Brener, Z. Andrade, & M. Barral-Netto (Eds.), Trypanosoma cruzi e doença de Chagas (2nd ed., pp. 201–230). Rio de Janeiro: Guanabara-Koogan.

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  • Andrade, S. G. (2005). Biodemas, zimodemas e esquisodemas: sua relação com a patologia da doença de Chagas. In J. R. Coura (Ed.), Dinâmica das Doenças Infecciosas e Parasitárias (pp. 621–637). Rio de Janeiro: Guanabara-Koogan.

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  • Andrade, S. G., Campos, R. F., Sobral, S. C., Magalhães, J. B., Guedes, R. S. P., & Guerreiro, M. L. (2006). Reinfections with strains of Trypanosoma cruzi, of different biodemes as a factor of aggravation of myocarditis and myositis in mice. Revista da Sociedade Brasileira de Medicina Tropical, 39, 1–8.

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  • Bittencourt, A. L. (1963). Placenta chagásica e transmissão da doença de Chagas. Revista do Instituto de Medicina Tropical de São Paulo, 5, 62–67.

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  • Carlier, V., & Torrico, F. (organizers). (2005). Colóquio Internacional Infección Congênita por Trypanosoma cruzi: desde los mecanismos de transmissión hasta una estratégia de diagnóstico y control. Revista da Sociedade Brasileira de Medicina Tropical, 38(Suppl. II), 1–128.

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  • Carvalho, C. M., Silverio, J. C., da Silva, A. A. et al. (2012). Inducible nitric oxide synthase in heart tissue and nitric oxide in serum of Trypanosoma cruzi-infected rhesus monkeys: Association with heart injury. PLoS Neglected Tropical Diseases, 6(5), e1644. doi:10.1371/journal.pntd.0001644. Epub 2012 May 8

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  • Coura, J. R. (2007). Chagas disease: what is known and what is needed – A background article. Memórias do Instituto Oswaldo Cruz, 102(Suppl. I), 113–122.

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  • Coura, J. R., & Dias, J. C. P. (2009). Epidemiology, control and surveillance of Chagas disease: 100 years after its discovery. Memórias do Instituto Oswaldo Cruz, 104, 31–40.

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  • Higuchi, M. L., Benvenuti, L. A., Martins, R. M., & Metzger, M. (2003). Pathophysiology of the heart in Chagas’ disease: Current status and new developments. Cardiovascular Research, 60, 96–107.

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  • Koberle, F. (1961). Patologia y anatomia patológica de la enfermedadde Chagas. Bol Ofic Sanit Panamer, 51, 404–428.

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  • Lannes-Vieira, J. (2003). Trypanosoma cruzi-elicited CD8+ T cell-mediated myocarditis: Chemokine receptors and adhesion molecules as potential therapeutic targets to control chronic inflammation? Memórias do Instituto Oswaldo Cruz, 98, 299–304.

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  • Teixeira, A. R. L., Nascimento, R. J., & Sturm, N. R. (2006). Evolution and pathology in Chagas disease – A review. Memórias do Instituto Oswaldo Cruz, 101, 463–491.

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  • www.fiocruz.br/chagas

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Author information

Authors and Affiliations

  1. Departamento de Diagnóstico Laboratorial – Serviço de Anatomia Patológica, Instituto Português de Oncologia Lisboa Francisco Gentil, IPOLFG, E.P.E, Lisbon, Portugal

    Rafaela L. Rego

  2. Serviço de Anatomia Patológica, Instituto Nacional do Cancer Rio de Janeiro, Praça Cruz Vermelha, 23 - Centro, Rio de Janeiro, RJ, 20230-130, Brasil

    Ivanir Martins

  3. Fundação Oswaldo Cruz (Fiocruz) Instituto de Pesquisa Clínica Evandro Chagas, Avenida Brasil, 4365, Manguinhos, 21040-360, Rio de Janeiro, Brasil

    Janice Mary Chicarino Coelho

  4. Departamento de Patologia, Universidade Federal Fluminense, R. Miguel de Frias, 9 - Icaraí, Niterói, 24220-008, Rio de Janeiro, Brasil

    Wilhermo Torres

Authors
  1. Rafaela L. Rego
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  2. Ivanir Martins
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  3. Janice Mary Chicarino Coelho
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  4. Wilhermo Torres
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Corresponding author

Correspondence to Rafaela L. Rego .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Rego, R.L., Martins, I., Coelho, J.M.C., Torres, W. (2017). Chagas Disease, Gastrointestinal Aspects. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1569

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1569

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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