Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Barrett’s Esophagus

  • Paula ChavesEmail author
  • António Dias Pereira
Reference work entry


Barrett’s metaplasia; Esophageal columnar metaplasia


Barrett’s esophagus (BE) results from the metaplastic replacement of the normal squamous esophageal lining by a columnar epithelium. Currently, there are two distinct definitions of BE stating two different proposals of patient’s management. The American Gastroenterological Association (AGA) defines BE as “the condition in which any extent of metaplastic columnar epithelium that predisposes to cancer development replaces the stratified squamous epithelium that normally lines the distal esophagus.” Currently, the AGA understanding is that “intestinal metaplasia is required for the diagnosis of Barrett’s esophagus because intestinal metaplasia is the only type of esophageal columnar epithelium that clearly predisposes to malignancy” (The AGA Institute Medical Position Panel 2011). The British Society of Gastroenterology (BSG), on the other hand, defines BE as “an endoscopically apparent area above the...

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References and Further Reading

  1. Dias Pereira, A., & Chaves, P. (2012). Columnar-lined oesophagus without intestinal metaplasia: Results from a cohort with a mean follow-up of 7 years. Alimentary Pharmacology & Therapeutics, 36, 282–289.CrossRefGoogle Scholar
  2. Goldblum, J. R. (2003). Barrett’s esophagus and Barrett’s-related dysplasia. Modern Pathology, 16, 316–324.CrossRefGoogle Scholar
  3. Hahn, H. P., Blount, P. L., Ayub, K., Das, K. M., Souza, R., Spechler, J. S., & Odze, R. D. (2009). Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus. The American Journal of Surgical Pathology, 33, 1006–1015.CrossRefGoogle Scholar
  4. Nurgalieva, Z., Lowrey, A., & El-Serag, H. B. (2007). The use of cytokeratin stain to distinguish Barrett’s esophagus from contiguous tissues: A systematic review. Digestive Diseases and Sciences, 52, 1345–1354.CrossRefGoogle Scholar
  5. Playford, R. J. (2006). New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett’s oesophagus. Gut, 55, 442–443.CrossRefGoogle Scholar
  6. The AGA Institute Medical Position Panel. (2011). American gastroenterological association medical position statement on the management of Barrett’s esophagus. Gastroenterology, 140, 1084–1091.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco GentilLisbonPortugal
  2. 2.Faculdade de Ciências da Saúde, Universidade da Beira InteriorCovilhãPortugal
  3. 3.Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E.LisbonPortugal