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Amyloidosis, Gastrointestinal

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  • First Online:
Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

  • 213 Accesses

Synonyms

Gastrointestinal manifestations of amyloidosis; Systemic amyloidosis

Definition

Amyloidoses are a diverse group of diseases characterized by abnormal folding of proteins and the extracellular tissue deposition of fibrils of low molecular weight subunits of normal serum proteins which disrupt tissue structure and function. The conversion of peptides or proteins from their insoluble functional states into highly organized fibrillar aggregates showing a cross-beta super-secondary structure is termed as “amyloid.” At least 28 different human proteins have been identified as amyloidogenic. Amyloidogenic deposition can be localized or systemic. Acquired causes of systemic amyloidoses include: (1) primary or AL amyloidosis in which the fibrils are composed of fragments of monoclonal light chains and affected patients may have amyloidosis alone or in association with other plasma cell dyscrasias, and (2) reactive (secondary) or AA amyloidosis in which the fibrils are composed of...

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References and Further Reading

  • Cowan, A., Skinner, M., & Seldin, D. et al. (2012) Amyloidosis of the gastrointestinal tract: A 13-year single center referral experience. Haematologica, 97. (epub ahead of print).

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  • Madsen, L. G., Gimsing, P., & Schiødt, F. V. (2009). Primary (AL) amyloidosis with gastrointestinal involvement. Scandinavian Journal of Gastroenterology, 44, 708.

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  • Merlini, G., Seldin, D., & Gertz, M. (2011). Amyloidosis: Pathogenesis and new therapeutic options. Journal of Clinical Oncology, 14, 1924–1933.

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  • Sattianayagam, P. T., Hawkins, P. N., & Gillmore, J. D. (2009). Systemic amyloidosis and the gastrointestinal tract. Nature Reviews. Gastroenterology & Hepatology, 6, 608–617.

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  • Tada, S., Iida, M., Yao, T., et al. (1994). Endoscopic features in amyloidosis of the small intestine: Clinical and morphologic differences between chemical types of amyloid protein. Gastrointestinal Endoscopy, 40, 45.

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Author information

Authors and Affiliations

  1. Serviço de Gastrenterologia, Centro Hospitalar de São João, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal

    Susana Rodrigues

Authors
  1. Susana Rodrigues
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Corresponding author

Correspondence to Susana Rodrigues .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Rodrigues, S. (2017). Amyloidosis, Gastrointestinal. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1560

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1560

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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