Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Adenocarcinoma, Upper Gastrointestinal Tract

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1554

Definition

The World Health Organization (WHO) has defined “adenocarcinoma” as “a malignant epithelial tumor with glandular differentiation” (WHO 2010). Esophageal adenocarcinomas arise primarily in the lower third of the esophagus from Barrett’s mucosa. Heterotopic gastric mucosa in the upper esophagus, mucosal, and submucosal glands can also give rise to adenocarcinomas of the esophagus. In the stomach, the most frequent site of “non-cardia” gastric cancer is the distal antro-pyloric region. In contrast to distal esophageal adenocarcinomas, there has been a steady decline in incidence of gastric (non-cardia) carcinoma over the last 15 years.

Adenocarcinoma of the esophagus, gastroesophageal junction (GEJ), and proximal stomach share many characteristics and risk factors. The incidence is increasing in high-resource countries; there is a high male:female ratio; and a higher incidence among whites and groups with higher socioeconomic status has been reported. In the last WHO...
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References and Further Reading

  1. Allum, W. H., Blazeby, J. M., Griffin, S. M., Cunningham, D., Jankowski, J. A., & Wong, R. (2011). Guidelines for the management of oesophageal and gastric cancer. Gut, 60(11), 1449–1472.PubMedCrossRefGoogle Scholar
  2. Bosman, F. T., Carneiro, F., Hruban, R. H., & Theise, N. D. (2012). WHO Classification of Tumours of the Digestive System (4th ed.). IARC Science Publication.Google Scholar
  3. Chen, S., Chen, Y., Yang, J., Yang, W., Weng, H., Li, H., et al. (2011). Primary mucoepidermoid carcinoma of the esophagus. Journal of Thoracic Oncology, 6(8), 1426–1431.PubMedCrossRefGoogle Scholar
  4. Chetty, R. (2012). Gastrointestinal cancers accompanied by a dense lymphoid component: An overview with special reference to gastric and colonic medullary and lymphoepithelioma-like carcinomas. Journal of Clinical Pathology, 65(12), 1062–1065.PubMedCrossRefGoogle Scholar
  5. Cirocchi, R., Trastulli, S., Desiderio, J., Grassi, V., Barillaro, I., Santoro, A., et al. (2012). Gastric carcinosarcoma: A case report and review of the literature. Oncology Letters, 4(1), 53–57.PubMedPubMedCentralGoogle Scholar
  6. Dye, D. W., Broadwater, R., & Lamps, L. W. (2005). Uncommon malignancies: Case 2. Gastric choriocarcinoma. Journal of Clinical Oncology, 23(25), 6251–6253.PubMedCrossRefGoogle Scholar
  7. Ferlay, J., Ervik, M., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., et al. (2013). GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11. from http://globocan.iarc.fr
  8. Geramizadeh, B., Nikeghbalian, S., & Abolghasem-Hosseini, S. (2010). Primary malignant rhabdoid tumor of the stomach, a rare case report and review of literature. Journal of Gastrointestinal Cancer, 41(4), 269–271.PubMedCrossRefGoogle Scholar
  9. Kakiuchi, M., Nishizawa, T., Ueda, H., Gotoh, K., Tanaka, A., Hayashi, A., et al. (2014). Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat Genet, 46(6), 583–587.Google Scholar
  10. Kim, Y. S., Kim, S. H., Seong, J. K., Lee, B. S., Jeong, H. Y., & Song, K. S. (2009). Gastric yolk sac tumor: A case report and review of the literature. The Korean Journal of Internal Medicine, 24(2), 143–146.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Kobayashi, A., Hasebe, T., Endo, Y., Sasaki, S., Konishi, M., Sugito, M., et al. (2005). Primary gastric choriocarcinoma: Two case reports and a pooled analysis of 53 cases. Gastric Cancer, 8(3), 178–185.PubMedCrossRefGoogle Scholar
  12. Na, Y. J., Shim, K. N., Kang, M. J., Jung, J. M., Ha, C. Y., Jung, H. S., et al. (2007). Primary esophageal adenoid cystic carcinoma. Gut and Liver, 1(2), 178–181.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Ng, W. C., Leong, H. T., Ma, K. F., Yip, W. L., & Suen, W. M. (2003). Malignant rhabdoid tumour of the oesophagus: A case report. Journal of Clinical Pathology, 56(9), 713–714.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005). Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians, 55(2), 74–108.Google Scholar
  15. Raza, M. A., & Mazzara, P. F. (2011). Sarcomatoid carcinoma of esophagus. Archives of Pathology & Laboratory Medicine, 135(7), 945–948.Google Scholar
  16. Shastri, A., Daver, N. G., & Hayes, T. G. (2011). Primary gastric chorioadenocarcinoma: A needle in a haystack. Rare Tumors, 3(2), e19.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Stolte, M., & Dostler, I. (2012). Good handling and pathological examination of endoscopic resections of early Barrett’s cancer. Diagnostic Histopathology, 18(21), 498–502.CrossRefGoogle Scholar
  18. Su, J. S., Chen, Y. T., Wang, R. C., Wu, C. Y., Lee, S. W., & Lee, T. Y. (2013). Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review. World Journal of Gastroenterology, 19(3), 321–327.PubMedPubMedCentralCrossRefGoogle Scholar
  19. Takubo, K., Honma, N., Sawabe, M., Arai, T., Izumiyama-Shimomura, N., Kammori, M., et al. (2002). Oncocytic adenocarcinoma of the stomach: Parietal cell carcinoma. The American Journal of Surgical Pathology, 26(4), 458–465.PubMedCrossRefGoogle Scholar
  20. The Cancer Genome Atlas Research Network (2017). Integrated genomic characterization of oesophageal carcinoma. Nature, 541, 169–175.Google Scholar
  21. Thiel, A., & Ristimaki, A. (2012). Gastric cancer: Basic aspects. Helicobacter, 17(Suppl 1), 26–29.PubMedCrossRefGoogle Scholar
  22. Wang, K., Yuen, S. T., Xu, J., Lee, S. P., Yan, H. H., Shi, S. T., et al. (2014). Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet, 46(6), 573–582.Google Scholar
  23. Yachida, S., Nakanishi, Y., Shimoda, T., Nimura, S., Igaki, H., Tachimori, Y., et al. (2004). Adenosquamous carcinoma of the esophagus. Clinicopathologic study of 18 cases. Oncology, 66(3), 218–225.PubMedCrossRefGoogle Scholar
  24. Zang, Z. J., Cutcutache, I., Poon, S. L., Zhang, S. L., McPherson, J. R., Tao, J., et al. (2012). Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nature Genetics, 44(5), 570–574.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Chella R. S. van der Post
    • 1
  • Fátima Carneiro
    • 2
  1. 1.Department of PathologyRadboud University Medical CenterNijmegenThe Netherlands
  2. 2.Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3SPortoPortugal