Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Adenoacanthoma

  • Helena Baldaia
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1553

Synonyms

Adenocarcinoma with squamous metaplasia

Definition

Adenoacanthomas are adenocarcinomas which contain foci of benign-appearing squamous metaplasia (Fenoglio-Preiser et al. 2008a). The literature is somewhat obscure on the subject of adenoacanthomas as this designation was previously used to refer to carcinomas with combined glandular and squamous components, regardless of the appearance (benign or malignant) of the squamous component. As such, much of the literature concerning adenoacanthomas actually describes adenosquamous carcinomas.

The origin of the squamous epithelium is subject to debate. Some authors believe that adenoacanthomas may arise from adenomas with squamous morules or squamous metaplasia (Fenoglio-Preiser et al. 2008a). A common view on the origin of neoplasias with glandular and squamous components in the colon is that they arise from direct stimulation, by repeated mucosal trauma, of uncommitted basal cells that are capable of differentiating into glandular...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008a). Epithelial neolasms of the stomach. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (p. 258). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  2. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008b). Epithelial neoplasms of the colon. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (p. 981). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  3. Frizelle, F. A., Hobday, K. S., Batts, K. P., & Nelson, H. (2001). Adenosquamous and squamous carcinoma of the colon and upper rectum: A clinical and histopathologic study. Diseases of the Colon and Rectum, 44(3), 341–346.PubMedCrossRefGoogle Scholar
  4. Ngo, N., Villamil, C., Macauley, W., & Cole, S. R. (1999). Adenosquamous carcinoma of the small intestine. Report of a case and review of the literature. Archives of Pathology & Laboratory Medicine, 123(8), 739–742.Google Scholar
  5. Redston, M. (2009). Epithelial neoplasms of the large intestine. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
  6. Ylagan, L. R., Scholes, J., & Demopoulos, R. (2000). Cd44: A marker of squamous differentiation in adenosquamous neoplasms. Archives of Pathology & Laboratory Medicine, 124(2), 212–215.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaCentro Hospitalar de São JoãoPortoPortugal