Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Short Gut Syndrome

  • Arzu EnsariEmail author
Reference work entry


Small intestinal insufficiency


Short bowel syndrome (SBS) refers to the clinical consequences including malabsorption resulting from loss of small bowel absorptive surface area either due to congenital defect or surgical resection or bypass. The syndrome is characterized by maldigestion, malabsorption, and malnutrition. SBS occurs when more than one half of the bowel is removed or missing, especially if terminal ileum and ileocecal valves are removed. After removal of a large portion of the small intestine, the remaining small intestine goes through a process of adaptation that increases its ability to absorb nutrients. The inner lining grows, increasing its absorptive surface area. Intestinal adaptation can take up to 2 years to occur. Clinical symptoms of SBS include diarrhea, fatigue, steatorrhea, weight loss, and edema. The diagnosis rests on the clinical history and routine laboratory tests revealing the deficiency of nutrients.

Clinical Features

  • Incidence


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References and Further Reading

  1. Rossi, T. M., Lee, P. C., Young, C., & Tjota, A. (1993). Small intestinal mucosa changes, including epithelial cell proliferative activity, of children receiving total parenteral nutrition (TPN). Digestive Diseases and Sciences, 38(9), 1608–1613.CrossRefGoogle Scholar
  2. Sigalet, D. L. (2001). Short bowel syndrome in infants and children: An overview. Seminars in Pediatric Surgery, 10(2), 49–55.CrossRefGoogle Scholar
  3. Wall, E. A. (2013). An overview of short bowel syndrome management: Adherence, adaptation, and practical recommendations. Journal of the Academy of Nutrition and Dietetics, 113(9), S2212–S2672.CrossRefGoogle Scholar
  4. Wilmore, D. W., & Robinson, M. K. (2000). Short bowel syndrome. World Journal of Surgery, 24(12), 1486–1492.CrossRefGoogle Scholar
  5. Wood, S. J., Khalil, B., Fusaro, F., Folaranmi, S. E., Sparks, S. A., & Morabito, A. (2013). Early structured surgical management plan for neonates with short bowel syndrome may improve outcomes. World Journal of Surgery, 37(7), 1714–1717.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolSihhiye, AnkaraTurkey