Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Peptic Duodenal Disease

  • Arzu EnsariEmail author
Reference work entry


Chronic (peptic) duodenitis; Chronic active duodenitis; Chronic nonspecific duodenitis; H. pylori-associated chronic duodenitis; Peptic ulcer disease


Peptic duodenal disease represents a continuum of the same disease process of acute and chronic inflammation of the duodenal mucosa resulting from the toxic effects of excess gastric acid. In the setting of increased gastric acid secretion, such as in antral predominant H. pylori gastritis, duodenal inflammation and ulceration may occur. Chronic H. pylori infection is highly associated with peptic disease of the duodenum in more than 80% of the cases. It is also commonly seen in patients who smoke, take NSAIDs chronically for other conditions, have renal insufficiency, or have duodenal immobility. The clinical picture is characterized by burning epigastric pain relieved with food ingestion. In severe cases the pain may be accompanied by nausea and vomiting.

Clinical Features

  • Incidence

    It is estimated to affect up to...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Dixon, M. F. (2000). Patterns of inflammation linked to ulcer disease. Baillière’s Best Practice & Research. Clinical Gastroenterology, 14(1), 27–40.CrossRefGoogle Scholar
  2. Suriani, R., Venturini, I., Actis, G. C., Rocca, G., Rizzetto, M., Cerutti, E., Mazzucco, D., Cardesi, E., & Zeneroli, M. L. (2004). Effect of Helicobacter pylori eradication on bulbitis and duodenal gastric metaplasia. Hepato-Gastroenterology, 51(55), 176–180.PubMedGoogle Scholar
  3. Voutilainen, M., Juhola, M., Farkkila, M., & Sipponen, P. (2003). Gastric metaplasia and chronic inflammation at the duodenal bulb mucosa. Digestive and Liver Disease, 35, 94–98.CrossRefGoogle Scholar
  4. Walker, M. M., & Dixon, M. F. (1996). Gastric metaplasia: Its role in duodenal ulceration. Alimentary Pharmacology and Therapeutics, 10, 119–128.CrossRefGoogle Scholar
  5. Wyatt, J. I., Rathbone, B. J., Sobala, G. M., Shallcross, T., Heatley, R. V., Axon, A. T. R., & Dixon, M. F. (1990). Gastric epithelium in the duodenum: Its association with H. pylori and inflammation. Journal of Clinical Pathology, 43, 981–986.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolSihhiyeTurkey