Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Pancreatic Heterotopia

  • Berna SavaşEmail author
Reference work entry


Aberrant pancreas; Accessory pancreas; Ectopic pancreas


Pancreatic heterotopia (PH), a congenital anomaly of the exocrine pancreas, is defined as the existence of the pancreatic tissue in topographic anomaly, with no anatomic, neural, or vascular connection to the main pancreas.

The exact etiology of ectopic pancreas remains unclear. Different theories have been proposed to explain its appearance, the transplantation of embryonic pancreatic cells to adjacent structures during axial rotation of the intestine being one of them. Moreover, embryonic buds that remain adhered to the primitive duodenum could be taken to proximal or distal sites during the growth and development of the gastrointestinal tract. The incidence of pancreatic tissue in distant organs should deserve further explanation, remembering the possibility of having been originated by multipotent cell endodermic metaplasia or teratomas.

Heterotopic pancreatic tissue is susceptible to many of the same...

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References and Further Reading

  1. Dabbs, D. J. (2010). Diagnostic immunohistochemistry. Theranostic and genomic applications. In O. Basturk, A. B. Farris, & N. V. Adsay (Eds.), Immunohistology of the pancreas, biliary tract and liver (pp. 541–592). Philapdelphia: Saunders/Elsevier.Google Scholar
  2. Emerson, L., Layfield, L. J., Rohr, L. R., & Dayton, M. T. (2004). Adenocarcinoma arising in association with gastric heterotopic pancreas: A case report and review of the literature. Journal of Surgical Oncology, 87, 53–57.CrossRefGoogle Scholar
  3. Lai, E. C., & Tompkins, R. K. (1986). Heterotopic pancreas. Review of a 26 year experience. American Journal of Surgery, 151, 697–700.CrossRefGoogle Scholar
  4. Solcia, E., Capella, C., & Kloppel, G. (1997). Tumors of the pancreas (pp. 146–148, 231–232). Washington, DC: Armed Forces Institute of Pathology. Atlas of tumor pathology; 3rd series, fascicle 20.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolAnkaraTurkey