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Pathology of the Gastrointestinal Tract pp 508–513Cite as

Mucinous Cystadenocarcinoma, Appendix

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

High-grade mucinous adenocarcinoma; Well-differentiated mucinous adenocarcinoma

Definition

An appendiceal adenocarcinoma is a malignant epithelial neoplasm of the appendix with invasion beyond the muscularis mucosae.

In the current UICC/AJCC TNM staging (7th edition, 2010), appendiceal adenocarcinomas are separated into mucinous and non-mucinous types (UICC/AJCC TNM staging 2010). Indeed, the 5-year survival of appendiceal mucinous adenocarcinomas with distant metastasis is significantly better than those of non-mucinous carcinomas. This is reflected in the staging considerations for metastatic tumors.

Macroscopically, mucinous adenocarcinomas of the appendix can be cystic or not. The term “mucinous cystadenocarcinoma” may be used for well-differentiated mucinous adenocarcinomas with cystic structures. However, the distinction between a cystic carcinoma (i.e., cystadenocarcinoma) and one that is not cystic has not been shown to be of biologic significance. Therefore, this...

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References and Further Reading

  • Carr, N. J., & Sobin, L. H. (2010). Tumours of the appendix. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 122–125). Lyon: IARC Press.

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  • Edge, S. B., Byrd, D. R., Compton, C. C., Fritz, A. G., Greene, F. L., & Trotti, A. (2010). Appendix. In AJCC Cancer Staging Handbook, from the AJCC cancer staging manuel, (7th ed., pp. 161–171). New York: Springer.

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  • National Cancer Institute Monograph 57. (1981). Surveillance, epidemiology, and end results: Incidence and mortality data, 1973–77 (NIH Publication No. 81–2330). Bethesda: US. Department of Health and Human Services.

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  • Sugarbaker, P. H. (2009). Comprehensive management of peritoneal surface malignancy using cytoreductive surgery and perioperative intraperitoneal chemotherapy: The Washington Cancer Institute approach. Expert Opin Pharmacother, 10, 1965–1977.

    Article  CAS  Google Scholar 

  • Thomas, R. M., & Sobin, L. H. (1995). Gastrointestinal cancer. Cancer, 75, 154–170.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Hôpital Saint-Antoine, Service d’Anatomie Pathologique, AP-HP, Hôpitaux Universitaires de l’Est Parisien, 184 rue du Faubourg Saint-Antoine, 75 012, Paris, France

    Magali Svrcek

Authors
  1. Magali Svrcek
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Corresponding author

Correspondence to Magali Svrcek .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Svrcek, M. (2017). Mucinous Cystadenocarcinoma, Appendix. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1512

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1512

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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