Mucinous Cystadenocarcinoma, Appendix
High-grade mucinous adenocarcinoma; Well-differentiated mucinous adenocarcinoma
An appendiceal adenocarcinoma is a malignant epithelial neoplasm of the appendix with invasion beyond the muscularis mucosae.
In the current UICC/AJCC TNM staging (7th edition, 2010), appendiceal adenocarcinomas are separated into mucinous and non-mucinous types (UICC/AJCC TNM staging 2010). Indeed, the 5-year survival of appendiceal mucinous adenocarcinomas with distant metastasis is significantly better than those of non-mucinous carcinomas. This is reflected in the staging considerations for metastatic tumors.
Macroscopically, mucinous adenocarcinomas of the appendix can be cystic or not. The term “mucinous cystadenocarcinoma” may be used for well-differentiated mucinous adenocarcinomas with cystic structures. However, the distinction between a cystic carcinoma (i.e., cystadenocarcinoma) and one that is not cystic has not been shown to be of biologic significance. Therefore, this...
References and Further Reading
- Carr, N. J., & Sobin, L. H. (2010). Tumours of the appendix. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 122–125). Lyon: IARC Press.Google Scholar
- Edge, S. B., Byrd, D. R., Compton, C. C., Fritz, A. G., Greene, F. L., & Trotti, A. (2010). Appendix. In AJCC Cancer Staging Handbook, from the AJCC cancer staging manuel, (7th ed., pp. 161–171). New York: Springer.Google Scholar
- National Cancer Institute Monograph 57. (1981). Surveillance, epidemiology, and end results: Incidence and mortality data, 1973–77 (NIH Publication No. 81–2330). Bethesda: US. Department of Health and Human Services.Google Scholar