Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Lymphoma and Immunoproliferative Small Intestinal Disease (IPSID)

  • Başak DoğanavşargilEmail author
Reference work entry


Intestinal lymphoma: “Western-type” intestinal lymphoma

Immunoproliferative small intestinal disease (IPSID): Alpha chain disease; Mediterranean lymphoma; Seligmann disease

Monomorphic epitheliotropic intestinal T-cell lymphoma: Defined as “Enteropathy-associated T-cell lymphoma type” in World Health Organization (WHO) classification of tumors of haematopoietic and lymphoid tissues in 2008 and as “Monomorphic CD56 (+) intestinal T-cell lymphoma” in WHO Classification of Tumours of the Digestive System in 2010. The 2016 revision of the classification of lymphoid neoplasms defines the entity as “Monomorphic epitheliotropic intestinal T-cell lymphoma.”


Intestinal Lymphoma (IL)

The definition of “intestinal lymphoma (IL)” varies among the authors as it can occur as a primary lesion or in a secondary fashion in a substantial portion of the cases. Usually a “primary” gastrointestinal (GI) lymphoma is considered when the main bulk of disease is located in GI tract with...

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References and Further Reading

  1. Al-Saleem, T., & Al-Mondhiry, H. (2005). Immunoproliferative small intestinal disease (IPSID): A model for mature B-cell neoplasms. Blood, 105, 2274–2280.CrossRefGoogle Scholar
  2. Arora, N., Manipadam, M. T., Pulimood, A., Ramakrishna, B. S., Chacko, A., Kurian, S. S., & Nair, S. (2011). Gastrointestinal lymphomas: Pattern of distribution and histological subtypes: 10 years experience in a tertiary centre in South India. Indian Journal of Pathology and Microbiology, 54, 712–719.CrossRefGoogle Scholar
  3. Bautista-Quach, M. A., Ake, C. D., Chen, M., & Wang, J. (2012). Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. Journal of Gastrointestinal Oncology, 3, 209–225.PubMedPubMedCentralGoogle Scholar
  4. Bosman, F., Carneiro, F., Hruban, R. H., & Theise, N. D. (Eds.). (2010). WHO classification of tumours of the digestive system. Lyon: IARC.Google Scholar
  5. Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., Thiele, J., & Vardiman, J. W. (Eds.). (2008). WHO classification of tumours of haematopoietic and lymphoid tissues (4th ed.). Lyon: IARC.Google Scholar
  6. Swerdlow, S. H., Campo, E., Pileri, S. A., Harris, N. L., Stein, H., Siebert, R., Advani, R., Ghielmini, M., Salles, G. A., Zelenetz, A. D., & Jaffe, E. S. (2016). The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood, 127, 2391–2405. pii: blood-2016-01-643569. [Epub ahead of print].CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyEge University Medical SchoolBornova, IzmirTurkey