Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Gangliocytic Paraganglioma, Duodenal

  • Saba KiremitciEmail author
Reference work entry


Nonchromaffin paraganglioma of the duodenum


Gangliocytic paraganglioma is a rare and unique neuroendocrine neoplasm which is currently classified as an epithelial tumor according to the classification of tumors of the digestive tract by the World Health Organization (WHO). The tumor reveals histologic and immunohistochemical features of both neural and endocrine tissues, and histologic diagnosis requires the presence of three different cell lineages: epithelioid cells resembling paraganglioma or well-differentiated neuroendocrine tumor; spindle cells reminiscent of Schwann cells; and ganglion or ganglion-like cells.

Gangliocytic paraganglioma has been considered as a hyperplastic or hamartomatous counterpart to the neoplastic duodenal well-differentiated neuroendocrine tumor (carcinoid), both derived from the same embryonic anlage. Although it is regarded as a benign neoplasm, the benign nature of this tumor is controversial due to the several reports of lymph node...

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References and Further Reading

  1. Burke, A. P., & Helwig, E. B. (1989). Gangliocytic paraganglioma. American journal of Clinical Pathology, 92(1), 1–9.PubMedGoogle Scholar
  2. Okubo, Y., Yokose, T., Tuchiya, M., et al. (2010). Duodenal gangliocytic paraganglioma showing lymph node metastasis: A rare case report. Diagnostic Pathology, 5, 27.PubMedPubMedCentralGoogle Scholar
  3. Okubo, Y., Nemoto, T., Wakayama, M., et al. (2015). Gangliocytic paraganglioma: A multi-institutional retrospective study in Japan. BMC Cancer, 15, 269.PubMedPubMedCentralGoogle Scholar
  4. Park, H. K., & Han, H. S. (2016). Duodenal gangliocytic paraganglioma with lymph node metastasis. Archives of Pathology and Laboratory Medicine, 140(1), 94–98.PubMedGoogle Scholar
  5. Snover, D. C., Ahnen, D. J., Burt, R. W., & Odze, R. D. (2010). Serrated polyps of the colon and rectum and serrated polyposis. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (4th ed.). Lyon: IARC.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolSihhiye, AnkaraTurkey