Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Eosinophilic Colitis

Reference work entry


Allergic colitis (proctitis or proctocolitis); Milk-protein proctocolitis


Eosinophilic colitis is a heterogeneous disorder characterized by the presence of a dense eosinophilic infiltration in the colon that can be segmental or diffuse (Fig. 1). It may affect children as well as adults. Three different types must be distinguished: primary eosinophilic colitis, which belongs to the family of primary eosinophilic gastrointestinal disorders (EGID), secondary eosinophilic colitis, and colitis in the framework of the hypereosinophilic syndrome (HES). Secondary eosinophilic colitis is observed in a variety of diseases such as idiopathic inflammatory bowel disease (IBD), parasitic and helminthic infections with Strongyloides stercoralis, Enterobius vermicularis, and drug-associated colitis. Drugs involved include clozapine, carbamazepine, gold salts, rifampicin, antiplatelet agents, tacrolimus, and naproxen. Other associations include vasculitis (Churg-Strauss),...
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References and Further Reading

  1. Casella, B., Villanaci, V., Fisogni, S., Cambareri, A. E., Di Bellas, C., Corazzi, N., Gorlas, S., Baldini, V., & Bassotti, G. (2009). Colonic left-side increase of eosinophils: A clue to drug-related colitis in adults. Alimentary Pharmacology & Therapeutics, 29, 535–541.CrossRefGoogle Scholar
  2. Gaertner, W. B., MacDonald, J. E., Kwaan, M. R., Shepela, C., Madoff, R., Jessurun, J., & Melton, G. B. (2011). Eosinophilic colitis: University of Minnesota experience and literature review. Gastroenterology Research and Practice, 2011, 857508.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Nguyen, T., Gernez, Y., Fuentebella, J., Patel, A., Tirouvanziam, R., Reshamwala, N., Bass, D., Berquist, W. E., Cox, K. L., Kerner, J. A., & Nadeau, K. C. (2011). Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis. Journal of Pediatric Gastroenterology and Nutrition, 53, 40–47.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Pascal, R. R., Gramlich, T. L., Parker, K. M., & Gansler, T. S. (1997). Geographic variations in eosinophil concentration in normal colonic mucosa. Modern Pathology, 10, 363–365.PubMedGoogle Scholar
  5. Polydorides, A. D., Banner, B. F., Hannaway, P. J., & Yantiss, R. K. (2008). Evaluation of site-specific and seasonal variation in colonic mucosal eosinophils. Human Pathology, 39, 832–836.CrossRefPubMedGoogle Scholar
  6. Powell, N., Walker, M. M., & Talley, N. J. (2010). Gastrointestinal eosinophils in health, disease and functional disorders. Nature Reviews. Gastroenterology & Hepatology, 7, 146–156.CrossRefGoogle Scholar
  7. Rothenberg, M. (2004). Eosinophilic gastrointestinal disorders (EGID). The Journal of Allergy and Clinical Immunology, 113, 11–28.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyN. Goormaghtig Institute, University GentGentBelgium
  2. 2.Department of PathologyKU LeuvenLeuvenBelgium