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Anal Adenocarcinoma

  • Reference work entry
  • First Online:
Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

  • 234 Accesses

Synonyms

Glandular carcinoma

Definition

The most frequent type of anal cancer is squamous cell carcinoma, described in a specific chapter (see entry “Squamous Cell Carcinoma, Anus”). Other types of anal carcinoma, i.e., adenocarcinoma, neuroendocrine carcinoma, Paget’s disease, and basal cell carcinoma, can also be observed.

Adenocarcinoma of the anal canal is a malignant epithelial tumor arising from glandular cells lining the upper anorectal part of the anal canal, anal transitional zone (ATZ) mucosa, the anal glands, or the epithelium lining of fistulous tracts.

Most adenocarcinomas found in the anal canal represent downward spread from a rectal adenocarcinoma or arise from colorectal-type mucosa lining the ATZ above the dentate line. Rare cases, described as extramucosal perianal adenocarcinomas, develop in pre-existing congenital or acquired anal sinuses or fistulae (in patients with Crohn’s disease). Some adenocarcinomas develop from anal glands or ducts that drain the anal...

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References and Further Reading

  • Meriden, Z., & Montgomery, E. A. (2012). Anal duct carcinoma: A report of 5 cases. Human Pathology, 43, 216–220.

    PubMed  Google Scholar 

  • Shia, J. (2010). An update on tumors of the anal canal. Archives of Pathology and Laboratory Medicine, 134, 1601–1611.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Service d’Anatomie Pathologique, Centre Hospitalier et Universitaire du Nord, Place Victor Pauchet, 80054, Amiens, France

    Denis Chatelain

  2. Faculté de Médecine Pierre et Marie Curie, Service d’Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, 184, rue du faubourg Saint-Antoine, Paris, France

    Jean-François Fléjou

Authors
  1. Denis Chatelain
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  2. Jean-François Fléjou
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Corresponding author

Correspondence to Denis Chatelain .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Chatelain, D., Fléjou, JF. (2017). Anal Adenocarcinoma. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1427

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1427

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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