Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Bacterial Overgrowth Syndrome

  • Arzu EnsariEmail author
Reference work entry


Blind loop syndrome; Small bowel bacterial overgrowth (SIBO) syndrome; Stasis syndrome


SIBO occurs when small bowel motility is altered under conditions causing luminal stasis and colonization of the normal microfloral bacteria in the lumen resulting in mucosal damage and malabsorption. Regardless of the underlying cause, SIBO is a very heterogeneous syndrome characterized by the presence of an increased number and/or abnormal type of bacteria normally confined to the colon, within the small intestine. Normally, small intestinal lumen is colonized by facultative anaerobe or obligate bacteria, particularly bacteroides species, which are predominantly found in the distal ileum, while proximal small intestinal mucosa is usually colonized by bacteria ingested with food. Bacteria in SIBO might significantly interfere with enzymatic, absorptive, and metabolic actions of the small intestinal mucosa. Any condition causing disruption of intestinal luminal flow including...

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References and Further Reading

  1. Bohm, M., Siwiec, R. M., & Wo, J. M. (2013). Diagnosis and management of small intestinal bacterial overgrowth. Nutrition in Clinical Practice, 28, 289–299.CrossRefGoogle Scholar
  2. Bures, J., Cyrany, J., Kohoutova, D., Förstl, M., Rejchrt, S., Kvetina, J., Vorisek, V., & Kopacova, M. (2010). Small intestinal bacterial overgrowth syndrome. World Journal of Gastroenterology, 16(24), 2978–2990.CrossRefGoogle Scholar
  3. Petrone, P., Sarkisyan, G., Fernández, M., Coloma, E., Akopian, G., Ortega, A., & Kaufman, H. S. (2011). Small intestinal bacterial overgrowth in patients with lower gastrointestinal symptoms and a history of previous abdominal surgery. Archives of Surgery, 146(4), 444–447.CrossRefGoogle Scholar
  4. Rana, S. V., & Bhardwaj, S. B. (2008). Small intestinal bacterial overgrowth. Scandinavian Journal of Gastroenterology, 43(9), 1030–1037.CrossRefGoogle Scholar
  5. Sachdeva, S., Rawat, A. K., Reddy, R. S., & Puri, A. S. (2011). Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: Frequency and predictors. Journal of Gastroenterology and Hepatology, 26(Suppl 3), 135–138.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolSihhiyeTurkey