Additive Manufacturing for Tissue Engineering

  • Solaleh Miar
  • Ashkan Shafiee
  • Teja Guda
  • Roger Narayan
Living reference work entry
Part of the Reference Series in Biomedical Engineering book series (RSBE)

Abstract

Additive manufacturing is becoming a focus of attention owing to its unique abilities to fabricate different objects using various materials. Perhaps printing technologies are the most popular type of additive manufacturing that is gaining ground in a wide range of industrial and academic utilization. Three- and two-dimensional printing of different materials such as ceramics, plastics, and metals as well as electronic functional materials is considered as the next revolution in science and technology. Importantly, these technologies are being used extensively in medical applications. Tissue engineering, which aims to fabricate human tissues and organs, is benefiting from the reproducible, computer-controlled, and precise procedure that can be obtained by printers. Three-dimensional printings of scaffolds, cell-laden biomaterials, and cellular (scaffold-free) materials hold a great promise to advance the tissue engineering field toward the fabrication of functional tissues and organs. Here, we review the utilization of different printing technologies for various tissue engineering applications. The application of printers in tissue engineering of bones, cartilages, and tendons and ligaments is di. Moreover, an overview of the advancements in printing skeletal muscles as well as the cardiovascular system is given. Finally, future directions and challenges will be described.

List of Abbreviations

ATST

Apparent tissue surface tension

AM

Additive manufacturing

ACL

Anterior cruciate ligament

CAD

Computer aided design

CADD

Computer aided design and drafting

DLP

Digital light processing

EBM

Electron beam melting

ECM

Extra cellular matrix

FDM

Fused deposition modeling

FFF

Fused filament fabrication

GAG

Glycosaminoglycan

HA

Hydroxyapatite

hPMSCs

Human placenta-derived mesenchymal stem cells

MHC

Myosin heavy chain

MSCs

Mesenchymal stem cells

PAM

Pressure-assisted microsyringe

PCL

Polycaprolactone

PED

Precision extrusion deposition

PEG

Polyethylene glycol

PEGDMA

Poly (ethylene glycol)dimethacrylate

PEO

Polyethylene oxide

PHBV

Poly (hydroxybutyrate-co-hydroxyvalerate)

PLA

Polylactic acid

PLDLLA

Poly (L-lactide-co-D,L-lactide)

PLGA

Poly-lactic-co-glycolic acid

PLLA

Poly (L-lactide) acid

PPF

Poly (propylene fumarate)

SEM

Scanning electron microscopy

SLA

Stereolithography

SLM

Selective laser melting

SLS

Selective laser sintering

TCP

Tricalcium phosphate

3D

Three-dimensional

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Solaleh Miar
    • 1
    • 2
  • Ashkan Shafiee
    • 3
  • Teja Guda
    • 1
    • 2
  • Roger Narayan
    • 4
    • 5
  1. 1.Department of Biomedical EngineeringUniversity of Texas at San AntonioSan AntonioUSA
  2. 2.Graduate Program in Biomedical EngineeringUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  3. 3.Wake Forest Institute for Regenerative MedicineWinston-SalemUSA
  4. 4.UNC/NCSU Joint Department of Biomedical EngineeringRaleighUSA
  5. 5.Diabetes Center for Research, Department of Biomedical EngineeringUNC School of MedicineChapel HillUSA

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