Abstract
Hyperkeratotic hand eczema is uncommon.
It is characterized by volar, often bilateral, and symmetric hyperkeratosis of the skin.
It is typically located centrally or proximally in the palms.
The hyperkeratotic skin tends to crack which may result in painful fissures.
First-line treatment options include topical corticosteroids, photochemotherapy, and retinoids.
Oral alitretinoin treatment represents an effective but expensive therapeutic option.
This is a preview of subscription content, log in via an institution to check access.
References
Agrup G (1969) Hand eczema and other hand dermatosis in South Sweden. Acta Derm Venereol 49:1–91
Baden HP (1974) Treatment of hyperkeratotic dermatitis of the palms. Sequential treatment with a keratolytic gel and corticosteroid ointment. Arch Dermatol 110:737–738
Bollag W, Ott F (1999) Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid. Dermatology 199:308–312
Boonstra MB, Christoffers WA, Coenraads PJ, Schuttelaar ML (2015) Patch test results of hand eczema patients: relation to clinical types. J Eur Acad Dermatol Venereol 29(5):940–947. https://doi.org/10.1111/jdv.12735. Epub 15 Sep 2014
Brans R, John SM (2016) Clinical patterns and associated factors in patients with hand eczema of primarily occupational origin. J Eur Acad Dermatol Venereol 30(5):798–805. https://doi.org/10.1111/jdv.13515. Epub 9 Dec 2015
De Rie MA, Van Eendenburg JP, Versnick AC et al (1995) A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema. Br J Dermatol 132:964–969
Diepgen TL, Andersen KE, Brandao FM et al (2009) Hand eczema classification: a cross-sectional, multicentre study of the aetiology and morphology of hand eczema. Br J Dermatol 160:353–358
Egawa K (2005) Topical vitamin D3 derivatives in treating hyperkeratotic palmoplantar eczema: a report of five patients. J Dermatol 32:381–386
Gunther S (1972) Topical administration of vitamin A acid (retinoic acid) in palmar keratoses: callosities, hyperkeratotic eczema, hypertrophic lichen planus, pityriasis rubra pilaris. Dermatologica 145:344–347
Hersle K, Mobacken H (1982) Hyperkeratotic dermatitis of the palms. Br J Dermatol 107:195–201
Meding B, Swanbeck G (1989) Epidemiology of different types of hand eczema in an industrial city. Acta Derm Venereol 69:227–233
Menne T, Bachmann E (1979) Permanent disability from skin diseases. A study of 564 patients registered over a six year period. Derm Beruf Umwelt 27:37–42
Mobacken H, Rosen K, Swanbeck G (1983) Oral psoralen photochemotherapy (PUVA) of hyperkeratotic dermatitis of the palms. Br J Dermatol 109:205–208
Ruzicka T, Larsen FG, Galewicz D et al (2004) Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial. Arch Dermatol 140:1453–1459
Ruzicka T, Lynde CW, Jemec GB et al (2008) Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol 158:808–817
Saeki H, Watanabe R, Tsunemi Y, Tamaki K (2009) Severe hyperkeratotic palmoplantar eczema (eczema tyloticum). J Dermatol 36:362–363
Schempp CM, Muller H, Czech W et al (1997) Treatment of chronic palmoplantar eczema with local bath-PUVA therapy. J Am Acad Dermatol 36:733–737
Schiener R, Gottlober P, Muller B et al (2005) PUVA-gel vs. bath-PUVA therapy for severe recalcitrant palmoplantar dermatoses. A randomized, single-blinded prospective study. Photodermatol Photoimmunol Photomed 21:62–67
Thestrup-Pedersen K, Andersen KE, Menne T, Veien NK (2001) Treatment of hyperkeratotic dermatitis of the palms (eczema keratoticum) with oral acitretin. A single-blind placebo-controlled study. Acta Derm Venereol 81:353–355
Warshaw EM (2004) Therapeutic options for chronic hand dermatitis. Dermatol Ther 17:240–250
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Thyssen, J.P., Menné, T. (2018). Hyperkeratotic Dermatitis of the Palms. In: John, S., Johansen, J., Rustemeyer, T., Elsner, P., Maibach, H. (eds) Kanerva’s Occupational Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-40221-5_19-2
Download citation
DOI: https://doi.org/10.1007/978-3-319-40221-5_19-2
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-40221-5
Online ISBN: 978-3-319-40221-5
eBook Packages: Springer Reference MedicineReference Module Medicine