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Neuroendocrinology of Energy Homeostasis

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Hypothalamic-Pituitary Diseases

Part of the book series: Endocrinology ((ENDOCR))

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Abstract

Body weight regulation consists of a series of complex and occasionally redundant mechanisms principally involving food intake and energy expenditure. Many hormones, nutrients, and neurotransmitters are involved in signaling hunger and satiety. This multitude of signals is integrated by the hypothalamus, which in turn acts by changing the hormonal secretion pattern. In addition, the homeostatic system is strongly influenced by the brain circuits involved in pleasure, resulting in a food intake that is based on hedonistic choices, rather than just biological need. However, alterations in the mechanisms controlling the pleasure and gratification derived from food might also induce an increase in weight.

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Authors and Affiliations

  1. Endocrinology Unit and Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, University of Bologna – S. Orsola-Malpighi Hospital, Bologna, Italy

    Valentina Lo Preiato, Valentina Vicennati, Silvia Garelli & Uberto Pagotto

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  1. Valentina Lo Preiato
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  2. Valentina Vicennati
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  3. Silvia Garelli
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  4. Uberto Pagotto
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  1. DepT of Endocrinology and Nutrition, Univ de Santiago de Compostela, Santiago de Compostela, Spain

    Felipe F. Casanueva

  2. Division of Endocrinology, Diabetol, University of Torino, Torino, Torino, Italy

    Ezio Ghigo

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Preiato, V.L., Vicennati, V., Garelli, S., Pagotto, U. (2018). Neuroendocrinology of Energy Homeostasis. In: Casanueva, F., Ghigo, E. (eds) Hypothalamic-Pituitary Diseases. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-38681-2_16-1

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