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microRNA Modulation

  • Living reference work entry
  • First Online:
Cell Engineering and Regeneration

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

Abstract

microRNAs are small and evolutionary conserved RNA molecules that vastly fine-tune protein expression at a posttranscriptional level. microRNA modulation has recently surfaced as powerhouse feeding the progress of novel strategies for tissue and cell engineering and regeneration. The field is growing exponentially each year and approaching clinical applications, with considerable progress in identifying biomarkers for personalized medical needs and also harnessing the therapeutic potential of these molecules to finely enhance tissue repair. This chapter aims to support beginner and expert researchers alike to delve into this emerging dynamic field. Within this chapter, we provide an overview of the biology and function of microRNAs and how they are being addressed within the tissue engineering and regenerative medicine (TERM) arena in terms of resources, applications, and development projection. Specific attention is given to the advances in the development of specialized delivery systems for microRNAs, which largely involves the application of biomaterial scaffolds, and to finalize, we review the proven therapeutic potential of microRNAs to date within the TERM space. Overall, this chapter underlines the exciting potential of microRNA modulation for cell engineering and regeneration.

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Acknowledgments

Work supported by the European Research Council (ERC) Grant Agreement n° 239685 and 665777 and the Science Foundation Ireland (SFI) funded AMBER Centre.

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Authors and Affiliations

  1. Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland

    Irene Mencía Castaño, Rosanne M. Raftery, Caroline M. Curtin & Fergal J. O’Brien

  2. Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland

    Irene Mencía Castaño, Rosanne M. Raftery, Caroline M. Curtin & Fergal J. O’Brien

  3. Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland

    Irene Mencía Castaño, Rosanne M. Raftery, Caroline M. Curtin & Fergal J. O’Brien

  4. Department of Biotechnology, BOKU - University of Natural Resources and Life Sciences Vienna, Vienna, Austria

    Johannes Grillari

  5. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

    Heinz Redl

  6. AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria

    Heinz Redl

Authors
  1. Irene Mencía Castaño
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  2. Rosanne M. Raftery
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  3. Caroline M. Curtin
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  4. Johannes Grillari
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  5. Heinz Redl
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  6. Fergal J. O’Brien
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Corresponding author

Correspondence to Fergal J. O’Brien .

Editor information

Editors and Affiliations

  1. Tulane Univ. Sch. of Medicine, New Orleans, LA, USA

    Jeffrey M. Gimble

  2. AUVA Center, Ludwig Boltzmann Institute for Experimen, Vienna, Austria

    Darja Marolt

  3. Human Development and Health, University of Southampton, Southampton, UK

    Richard Oreffo

  4. Experimental and Clinical Traumatol, Ludwig Boltzmann Institute for, Wien, Austria

    Heinz Redl

  5. AUVA Center, Ludwig Boltzmann Institute for Experimen, Vienna, Austria

    Susanne Wolbank

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Castaño, I.M., Raftery, R.M., Curtin, C.M., Grillari, J., Redl, H., O’Brien, F.J. (2019). microRNA Modulation. In: Gimble, J., Marolt, D., Oreffo, R., Redl, H., Wolbank, S. (eds) Cell Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-37076-7_34-1

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  • DOI: https://doi.org/10.1007/978-3-319-37076-7_34-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-37076-7

  • Online ISBN: 978-3-319-37076-7

  • eBook Packages: Springer Reference EngineeringReference Module Computer Science and Engineering

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