Neurodegenerative Disorders

  • Nages Nagaratnam
  • Kujan Nagaratnam
  • Gary Cheuk
Reference work entry


Alzheimer’s disease primarily a neurodegenerative disorder is the commonest cause of dementia followed by vascular dementia. Alzheimer’s disease is a disorder of the amyloid precursor protein (APP), the frontotemporal (FTD) syndromes and some of the extrapyramidal dementias (corticobasal, progressive supranuclear palsy) are associated with the microtubule – associated protein tau. Other degenerative diseases including Parkinson’s disease, multiple system disease and Lewy Body dementia are associated with a – synuclein. The review provides an overview of the neyodegenerative dementias.


Alzheimer’s disease Lewy body dementia Amyloid precursor protein The frontotemporal (FTD) syndromes Extrapyramidal dementias 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Nages Nagaratnam
    • 1
  • Kujan Nagaratnam
    • 1
  • Gary Cheuk
    • 2
  1. 1.The University of SydneyWestmead Clinical SchoolWestmeadAustralia
  2. 2.Rehabilitation and Aged Care ServiceBlacktown-Mt Druitt HospitalMount DruittAustralia

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