Abstract
MSA can cause combinations of Parkinsonism, autonomic, pyramidal and cerebellar symptoms. MSA-A is now the term used for Shy-Drager syndrome, MSA-C if cerebellar symptoms predominate and MSA-P if Parkinsonian features predominate. The aetiology is uncertain although recently it has been attributed to a human prion composed of the alpha-synuclein protein. This chapter gives a concise account of the demographic, clinical characteristics and management of the disease.
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References
Hain TC. Multiple System Atrophy (MSA),. http://www.dizziness-and-balance.com/disorders/central/movement/msa.html accessed on 10 May 2016.
Ben-ShlomoY, Wening GK, Tison F, Quinn NP. Survival of patients with pathologically proven multiple system atrophy. A meta analysis. Neurology. 1997;48:384–39.
Best C. MSA Management strategies. EPNN Journal Winter 2007.
Quinn NP, Marsden CD. The motor disorder of multiple system atrophy/ Editorial. J Neurol Neurosurg Psychiatry. 1993;56 1239–1242.
Papapetropoulos S, Thchman A, Laufer D, Papatsoris AG, Papapetropoulos N, Mash DC. Causes of death in multisystem atrophy. J Neurol Neurosurg Psychiatry. 2006; 78(2):327–329.
Tada M, Onodera O, Tada M, Ozawa T, PiaoY, Kakita A, et al. Early development of autonomic dysfunction predict poor prognosis in patients with multisystem atrophy. Arch Neurol. 2007;64(2):256.
Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, et al. Progression and prognosis in Multisystem atrophy: an analysis of 230 Japanese patients. Brain. 2002;125(Pt 5):1070.
Lee PH, Kim JW, Bang OY, Ahn YH, Joo IS, HuhK. Autologous mesenchymal stem cell therapy delay the progression of neurological deficits. Clin Pharmacol Therapeutics. 2000;83:723–730.
Stefanova N, Bucke P, Duerr S, Wenng GK. Multiple system atrophy: an update .Lancet Neurol. 2009;8(12):1172–8.
Goldstein DS, Holme S, Li ST, Bruce S, Metman LV.Cannon RO 3rd. Cardiac sympathetic denervation in Parkinson’s disease. Ann Intern Med. 2000;133:338–347.
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Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2018). Multisystem Atrophy (MSA). In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-33434-9_41
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DOI: https://doi.org/10.1007/978-3-319-33434-9_41
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