Abstract
Peripheral neuropathy can be defined as a syndrome characterized by muscle weakness and wasting, altered or loss of sensation and vasomotor symptoms. It is less common in the old-old (>80 years) compared to the young-old (65–79 years), 25% vs. 46%. It may affect a single nerve or nerve root (axonopathy or radiculopathy). The nerve cell body may be the primary site of involvement (neuronopathy) and the sensory or autonomic ganglia (ganglioneuropathies). There are several causes. The clinical manifestations of neuropathy depend on the type, distribution and degree of damage of the nerve(s). Diabetes and alcoholism are the most common causes of polyneuropathy in Australia. Guillain-Barre syndrome (GBS) is the third most common. GBS has a bimodal age distribution, one peak in the young and another in the older population. GBS can be divided into demyelinating and axonal forms based on pathological and electrodiagnostic findings. They are the acute inflammatory demyelinating polyradiculopathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy (AMSAN), Miller Fisher syndrome and panautonomic neuropathy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Verghese J, Biari PL, Gellido C, Schaumburg HH, Herskovitz S. Peripheral neuropathy in young-old and old-old patients. Muscle & Nerve. 2001;24:1476–1481.
Hahn AF, Guillain-Barre syndrome. Lancet. 1998;352:635–41.
Hughes RAC. Peripheral neuropathy. BMJ. 2002;324(7335):466–469.
Camdessanche JP, Jousserand G, Ferraud K, Vial C, Petiot P, Honnorat J, et al. The pattern and diagnostic criteria of sensory neuropathy: a case-control study. Brain 2009;132(Pt7):1723–33. (abstract).
Kuntzer T. Ganglionopathies: evolving concept and ideas on management. Rev Neurol (Paris) 2006;162(12):1268–72.
Kumar N.B. Neurological aspects of cobalamin (B12) deficiency. Handb Clin Neurol. 2014;120:915–26.
Wynn M, Wynn A. The danger of B12 deficiency in the elderly. Nutr Health. 1998;12:215–26.
Scherer K. Neurologic manifestation of vitamin B12 deficiency. NEJM. 2003;348:2208. https://doi.org/10.1056/NEJMicm020588.
Saperstein DS, Barotin, RJ. Peripheral neuropathy due to cobalamin deficiency. Current Treatment Options. Neurology. 2002;4:197–201.
Chin RL. Neuropathology and the gastrointestinal system. http://www.neuropathy.org/site/DocServer/nutritional. GI-RussellCMD.pdf?docID=1601.
Lin K, Kwan SY, Chen SY, ChenSS, Yeung KB, Chia LG, et al. Generalised neuropathy in Taiwan: an etiologic survey. Neuroepidemiology. 1993;12:257–9.
Bolton CF. Sepsis and the systemic inflammatory response syndrome: neuromuscular syndrome. Crit Care Med. 1996;24:1408–16.
Bolton CF, Gilbert JJ, Hahn AF, Sibbald WJ. Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry. 1984;47:1223–1231.
Nagaratnam N, Jamieson G, Chiu K, Ramos C. Critical illness neuropathy. Neurorehab Neural Repair. 2001;15:49–52.
Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock: pathogenesis. Lancet 1991;338:732–6.
Ludolph AC, Spencer PS. Toxic neuropathies and their treatment. Baillieres Clin Neurol. 1995;4(3):505–27.
Hughes RA, Comblath DR. Guillain-Barre syndrome. Lancet. 2005;366(9497):1653–66.
Vucic S, Kierman MC, Comblath DR. Guillain-Barre syndrome: an update. J Clin Neurosci. 2009;16(6):733–41.
Newswanger DL, Warren CR. Guillain-Barre Syndrome. Am Fam Physician. 2004. http://www.aafp.org/afp/20040515/2405.html.
Odaka M, Yuki N, Hiurata K. Anti-GQib IgG antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry. 2001;70(1):50–5.
Winner SJ,Grimely EJ. Age-specific incidence of Guillain-Barre syndrome in Oxfordshire. QJM 1990;77(3):1297–1304.
DanielS, Green R. Guillain-Barre’ Syndrome. wwwfrca.co.uk/Documents/238GuillainBarreSyndrome.pdf. accessed 2 August 2016.
Kuwabara S. Guillain-Barre’ syndrome: epidemiology, pathophysiology and management. Drugs. 2004;64(6): 697–610.
Odaka M, Yuki N. Variants and differential diagnosis of Guillain-Barre syndrome. Expert Review Neurology. 2002;2(6):877–889.
The prognosis and main prognostic indicators of Guillain-Barre’ syndrome: a multicentre prospective study of 297 patients. The Italian Guillain-Barre’ Study Group. 1996;119;(pt 6): 2053–61.
Ropper AH. Guillain-Barre syndrome. N Engl J Med 1992;328:1130–6.
Hughes RA, Hadden RD, Gregson NA, Smith KJ. Pathogenesis of Guillain-Barre syndrome. J Neuroimunol. 1999;100(1–2):74–97.
Thomas M, Allen SC Guillain-Barre’ syndrome. in elderly patients. JHK Geriatr Soc. 1995;6:11–13.
Mayo Clinic Staff. Diseases and conditions: Botulism. http://www.mayoclinic.org/diseases-conditions/botulism/basics/symptoms/con-20025875 retrieved 14 February 2015.
Longina L, Donughy M. Diphtheritic polyneuropathies: A clinical study and comparison with Guillain-Barre Syndrome. J Neurol Neurosurg Psychiatry. 1999;87(4):433–438.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Pachner AR, et al. Clinical manifestations of Lyme disease. Zentralbl Bakteriol Mikrobio Hyg A. 1996;263(1–2):201–5.
Baraba R, Sruk A, Sragalj L, Butkovic-Soldo S, Bielen I. Electrophysiological findings in early Guillain-Barre syndrome. Acta Clin Croat. 2011;50(2):201–7.
Kimoto K, Koga M, Odaka M, Hirata K, Takihashi M, Li J, et al. Relationship of bacterial strains to clinical syndromes of Camphylobacter associated neuropathies. Neurology. 2006;67(10):1837–43
Alshekhlee A, Hussai Z, Sultan B, Katirji B. Guillain-Barre syndrome: incidence and mortality rates in US hospitals. Neurology. 2008;70:1608–1613.
Sridharan GV, Tallis RC, Gautam PC. Guillain-Barre syndrome in the elderly. A retrospective comparative study. Gerontology. 1993;39(3):170–5.
Leung SS. Guillain-Barre syndrome in elderly people. J Am Geriatr Soc. 2008;56:381–382.
Franca MC, Deus-Silva L, de Castro R, Garibaldi SG, Pfeilsticker BHM, Nucci A, Marques Jr FFC. Guillain-Barre syndrome in the elderly: clinical electrophysiological therapeutic and outcome features. Arq Neuro-Pisquiatr 2005;63(3b): https://doi.org/10.1590/S0004-282x2005000500010.
Yan WX, Archelos JJ, Hartung H-P, Pollard JD. Po protein is a target antigen in chronic inflammatory demyelinating polyradiculopathy. Ann Neurol 2001;50:286–292.
Shields RW Jr. Peripheral Neuropathy. Cleveland Clinic. Center for Continuing Education. http://www.clevelandclinic meded.com/medicalpubs/diseasemanagement/neurology/per accessed on 2 April 2014.
Willison HJ, Winer JB. Clinical examination and investigation of neuropathies. J Neurol Neurosurg Psychiatry 2003;74:ii3–li8. https://doi.org/10.1136/nnp.74.supp_2,ii3
Pan Yi. Uremic neuropathy. Emedicine.medscape.com/article1175425. accessed 25 Aust 2016.
Strait S, Medcalf P. Peripheral neuropathy in older people. GM 42.November 2012. http://www.gmjournal.co.uk/Peripheral _neuropathy_in_oder_People__29143.aspx accessed on 11 November 2015.
Richardson JK. Peripheral neuropathy: an often overlooked cause of falls in the elderly. Postgrad Med. 1996;99(6):161–72.
Vinik AI, Stritmeyer ES, Nakave AA, Patel CV. Diabetic neuropathy in older adults. Clin Geriatr Med. 2008;24(3):407–v.
Sorock GS, Labiner DM. Peripheral neuromuscular dysfunction and falls in a elderly cohort. Am J Epidemiol. 1992;136:584–91.
Mold JW, Vesely SK, Keyl BA, Schenk JB, Roberts M. The prevalence predictors and consequences of peripheral sensory neuropathy in older patients. Jam Board Fam Med. 2004;17(5):309–318.
Maty SC, FriedLP, Volpato S, Williamson J., Brancati FC, Blaum CS. Patterns of disability related to diabetes mellitus in older women. J Gerontol Biol Sci Med Sci. 2004;59:148–153.
Richardson JK, Thies SB, De Mott TK, Ashton-Miller JA. A comparison of gait characteristics between men with or without peripheral neuropathies in standard and challenging environments. J Am Geriatr Soc. 2004;52:1532–1537.
Menz HB, Lord SR, St George R, Fitzpatrick RC. Walking stability and sensorimotor function in older people with diabetic neuropathy. Arch Phys Med Rehab. 2004;85:245–252.
Azidah AK, Hasniza H, Husmati LY. Peripheral neuropathy among the elderly: diabetes in a Tertiary Center Malaysia. Int J Collaborative Res Int Med Pub Health. 2014;6(3):64–72.
Vickova-Moravcova E, Bednarik J. Painful sensory neuropathies in the elderly. Scripta Medica 2009;1–5. http://www.medmuni.cz/biomedjournal/737-archive?clanek+3 accessed11 November 2015.
Wlassoff V. Vitamin B12 deficiency and its neurological consequences. Neuroscience &Neurology. Brain Blogger. http://brainblogger.com/2014/07/30/vitamin-B12-deficincy-and-its-neurological-cnsequences. Accessed 11 November 2015.
Sethi N, Robilotti E, Sadan Y. Neurological manifestations of vitamin B-12 deficiency. Int Sci Pub http://ispub.com/IJNW/2?1/4476 accessed 11 November 2015.
George J, Twomey JA. Causes of polyneuropathies in the elderly. Age Ageing. 1986;15:247–249.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this entry
Cite this entry
Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2018). Peripheral Neuropathy. In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-33434-9_38
Download citation
DOI: https://doi.org/10.1007/978-3-319-33434-9_38
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-33433-2
Online ISBN: 978-3-319-33434-9
eBook Packages: MedicineReference Module Medicine