Abstract
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease. The usual age of onset is between 20 and 40 years. Late-onset multiple sclerosis (LOMS) is defined as the first presentation of clinical symptoms occurring after the age of 50 years. The two groups ‘adult-onset’ multiple sclerosis (AOMS) and ‘late-onset’ multiple sclerosis (LOMS) defer in their demographic, clinical characteristics, disease course and response to treatment. Multiple sclerosis is extremely protean in its expression and severity. Based on the clinical course, MS has been categorized into (i) relapsing remitting MS (RRMS), (ii) secondary progressive MS (SPMS), (iii) primary progressive MS (PPMS) and (iv) progressive-relapsing (PRMS). About 80% of LOMS are affected by PPMS. About 94% of the patients with AOMS had RRMS. The diagnosis is based on careful clinical evaluation of the patient with investigations including MRI, CSF and evoked potentials. Treatment can be divided into treatment of the relapses, long-term immunomodulatory treatment and symptomatic relief. Patients often require care from a multidisciplinary team of healthcare providers.
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References
Pender MP. Neurology.4:Multiple sclerosis. Med J Aust. 2000;172(11):556–62.
Brownlee WJ, Miller DH. Clinically isolated syndromes and the relationship to multiple sclerosis. J Clin Neurosci. 2014;21(12):2065–71.
Hurwitz BJ. The diagnosis of multiple sclerosis and the clinical subtypes. Ann Indian Acad Neurol. 2009;12(4):226–230.
Miller DH, Chard DT, Ciccarelli O. Clinically isolated syndromes. Lancet Neurol. 2012;11(2):157–69.
Swain SE. Multiple sclerosis. Primary health care implications. Nurse Pract. 1996;21(7):40,43,47–50.
Simo M. Therapy of multiple sclerosis. Neuropsychopharmacol Hung 2009;11(1):23–6.
Redjak K, Jsckson S, Giovannoni C. Multiple sclerosis: a practical overview for clinicians. Brit Med Bull. 2010; 95(1):79–104.
Kisv B, Rumberg B, Berlet P. Clinical characteristics of patients with late-onset multiple sclerosis. J Neurol. 2008;255:697–702.
Lynch SG, Rose JW. Multiple sclerosis. Dis Mon. 1996;42(1):1–55.
Ebers GC. Natural history of primary progressive multiple sclerosis. Mult Scier. 2004; 10Suppl 1:S8–13.
Orton SM, Herrera BM,Yee IM, Valdar W, Ramagopalan SV,Sadovnick AD, et al. Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurol. 2006;5(11):932–936.
Pender MP, Burrows SR. Epstein-Barr virus and multiple sclerosis: potential opportunities for immunotherapy. Clin Transl Immunology. 2014;31(3):e27. https://doi.org/10.1038/cti.2014.25.eCollection 2014.
Martinelli V, Rodegher M, Moiola L, Comi G. Late-onset multiple sclerosis: clinical characteristics, prognostic factors and differential diagnosis. Neurol Sci. 2004;25Suppl 4:S350–5. (abstract).
Pollack ML, Barak Y, Achiron A. Late-onset multiple sclerosis. J Am Geriatr Soc. 2001;49(2):168–71.
Shirani A, Zhan Y, Petkan J, Gustafson P,Karom ME, Evans C, et al. Multiple sclerosis in older adults: The clinical profile and impact of interferon beta treatment. BioMEd Res International 2015 (2015). https://doi.org/10.1155/2015/451912.
Delalande S, De Seze J Ferriby D, Stojkovic T, Vermersch P. Late onset multiple sclerosis. Rev Neurol (Paris). 2002;158(11):1082–7.
Bove R, Healy BC, Augustine A, Gholipour T, Chitnis T. Effect of gender on late–onset multiple sclerosis. Research Gate. https://doi.org/10.1177/1352458512438236.
Tsang BK, Macdonell R. Multiple sclerosis-diagnosis, management and prognosis. Aust Fam Physician. 2011;40(12):948–55.
Swanton JK, Fernando KT, Dalton CM, Miszkiel KA, Thompson AJ, Plant GT, et al. Modification of MRI criteria for multiple sclerosis in patients with clinically isolated syndromes. J Neurol Neurosurg Psychiatry. 2006;77:830–3.
Tintore M, Riviera A, Rio J, Nos C, Grive E, Tellez N, et al. Baseline MRI predicts future attacks and disability in clinically isolated syndromes. Neurology. 2006;67:968–72.
Beck RW, Trobe JD, Moke PS, Gal RL, Xing D, Bhatti MT, et al. High-and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: Experience of the optic neuritis treatment trial. Arch Ophthalmol 2003;121:944–9.
Tramlett H, Devonshire V. Is late onset multiple sclerosis associated with worse outcome? Neurology. 2006;67:954–959.
Traboulsee AL, Li DK. The role of MRI in the diagnosis of multiple sclerosis. Adv Neurol. 2006;98:125–46.
Milo R, Miller A. revised diagnostic criteria of multiple sclerosis. Autoimmun. 2014;13(4–5):518–24.
Confavreux C, Vukusic S. The natural history of multiple sclerosis. Rev Pract. 2006;56(12):1313–20.
Bitsch A, Bruck W. Differentiation of multiple sclerosis. Subtypes. CNS Drugs. 2002;16(6):405–418.
Fox EJ. Management of worsening multiple sclerosis with mitoxantrone: a review. Clin Ther. 2006;28(4):461–74.
Scott LJ, Figgitt DP. Mitoxantrone: a review of its use in multiple sclerosis. CNS Drugs. 2004;18(6):379–96.
Marrie RA, Yu J, Blanchard S, Leung S, Eliott L. The rising prevalence and changing age distribution of multiple sclerosis in Manitoba. Neurology. 2010;74(6):465–471.
Simpson RJ, McLean G, Guthrie M, Mair E, Mercer SW. Physical and mental health comorbidity is common in people with multiple sclerosis: nationally representing cross-sectional population database analysis. BMC Neurology. 2014 https://doi.org/10.1186/1471-2377-14-128.
Opara J, Jaracz K, Brola W. Burden and quality of life in caregivers of persons with multiple sclerosis. Neurol Neurochir Pol. 2012;46(5):472–9.
Paparrigopoulos T, Ferentinos P, Kouzoupis A, Koutsis G, Papadimitriou GN. The neuropsychiatry of multiple sclerosis: focus on disorders of mood, affect and behaviour. Int Rev Psychiatry. 2010;22(1):14–21.
Aikens JE, Fischer JS,Namey M, Rudick RA. A replicated prospective investigation of life stress, coping and depressive symptoms in multiple sclerosis. J Behav Med. 1997;20(5):433–45.
Mohr DC. Dick LP, Russo D, Pinn J, Boudewyn AC, Likosky W, et al. The psychological impact of multiple sclerosis: exploring the patient’s perspective. Health Psychol. 1999;18(4):376–82.
Dunn J. Impact of mobility impairment on the burden of caregiving in individuals with multiple sclerosis. Expert Rev Pharmacoecon Outcomes Res. 2010;10(4):433–40. https://doi.org/10.1586/erp.10.
Confavreux C, Vukusic S. Age at disability milestones in multiple sclerosis. Brain. 2006;129(Pt3):595–605.
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Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2018). Multiple Sclerosis. In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-33434-9_36
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DOI: https://doi.org/10.1007/978-3-319-33434-9_36
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