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Acute Kidney Injury

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Geriatric Diseases

Abstract

The term acute kidney injury (AKI) had been proposed to embrace the entire spectrum of syndrome from minimal changes in renal function to the need for renal replacement therapy (RRT). The elderly are susceptible to AKI due to a number of factors such as structural and functional changes due to ageing; functional impairment of kidneys secondary to diseases such as hypertension, heart failure and arteriosclerosis, increased susceptibility to nephrotoxins, dehydration and alterations in drug metabolism and clearance associated with ageing. The prognosis is dependent on a number of factors such as type, cause, severity, other disease processes among others. The review provides an overview of acute kidney injury, prevalence and mechanisms followed by clinical management.

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References

  1. Kellum JA. Acute kidney injury. Crit Care Med. 2008;36: S141–5.

    Article  PubMed  Google Scholar 

  2. Peacock Jr PR, Sinert R. Renal failure .acute http://emedicine.mediscape.com/article/777845-overview

  3. Kellum JA, Heste EA. Acute kidney injury: epidemiology and assessment. Scand J Clin Lab Invest. Suppl.2008;241:6–11.

    Article  PubMed  Google Scholar 

  4. Chung KK, Stewart IJ, Gisler C, Simmons JW, Aden JK, Tiley MA, et al. The Acute Kidney Injury Network (AKIN) criteria applied in burns. J Burns Care Res. 2012; 33(4):483–94.

    Article  Google Scholar 

  5. Bellomo R, Kellum JA,Ronco C Defining acute renal failure: Physiological principles. Intensive Care Med 2004;30: 33–37.

    Article  PubMed  Google Scholar 

  6. Bellomo R, Ronco C, Kellum JA, Metha RL, Palevsky P. Acute renal failure-Definition,outcome measures, animal models, fluid therapy and information technology needs: The Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8:R204-R212.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kellum J A, Bellomo R, Ronco A. Definition and classification of acute kidney injury. Nephron Clin Pract. 2008;109:c182-c187.

    Article  PubMed  Google Scholar 

  8. Musso CG, Liakopoulos Ioannidisi I, Eleftheriadis T, Stefani T. Acute renal failure in the elderly: particular characteristics. Int Urol Nephrol. 2006;38:787–793.

    Article  PubMed  Google Scholar 

  9. Levin ML. Acute renal failure in the elderly. Strategies forprevention. How the physiological effects of agng increases nephrotoxic risk. J Clon Illn. 1995;(1011):783–6.

    Google Scholar 

  10. Baraldi A, Ballestri M, Rapana R, Luichi L, Borella P, Leonelli M, et al. Acute renal failure of medical type in an elderly population.-NCB1.

    Google Scholar 

  11. Pascual J, Liano F, Ortuno J. The elderly patient with acute renal failure. J Am Soc Nephrol. 1995;6(2):144–53.

    CAS  PubMed  Google Scholar 

  12. Pascual J, Orofino L, Liano F, Marcen R, Naya MT, One L, et al. Incidence and prognosis of acute renal failure in older patients. J Am Geriatr Soc. 1990;38(1):25–30.

    Article  CAS  PubMed  Google Scholar 

  13. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimats H, Mogera S, et al. Acute renal failure in critical ill patients: A multinational, ynchronous study. JAMA. 2005;295:813–818.

    Article  Google Scholar 

  14. Davidman M, Olson P, Kohen J, Leither T, Kjellstrand C. Iatrogenic renal disease. Arch Intern Med. 1991;151:1809–1812.

    Article  CAS  PubMed  Google Scholar 

  15. Jerkic M, Vojvodic S, Lopez-Novoa JM. The mechanism of increased renal susceptibility to toxic substances in the elderly. Part !. The role of ncreased vasoconstriction. Int Urol Nephrol. 2001;32(4):539–47.

    Article  CAS  PubMed  Google Scholar 

  16. Lameire N, Hoste E, Van Loo A, Dondt A, Bernaert P, Vanholder R, et al. Pathopphysiology ,causes and prognosis of acute renal failure in the elderly. Renal Failure 1996;18:333–346. In rats. Toxicol Appl Pharmacol 1987;87:284–296.

    Google Scholar 

  17. Abdel-Kader K, Paevsky P. Acute kidney injury in the elderly. Clin Geriatr Med. 2009;25(3):331–358.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Andreucci VE, Fuiano G, Russo D, Andrecucci M. Vasomotor nephropathy. Nephrol Dial Transplant. 1998;13(Supp l7):17–24.

    Article  PubMed  Google Scholar 

  19. Anderson S. Fluid and electrolyte disorders in the elderly. In: Kokko JP, Tannen RL eds. Fluid and electrolytes. Saunders, Philadelphia, PA:1996:831–839.

    Google Scholar 

  20. Mandal AK, Baig M, Koutoubi Z. Management of acute renal failure in the elderly. Treament Options. Drugs Aging. 1998;9(4): 219–250.

    Google Scholar 

  21. Rose BD, Post TW. NSAIDS: Acute kidney injury (acure renal failure). And nephrotic syndrome http://wwwupdate.com/patients/content/topic.do?topicKey=gjS/LK_CKVuPo retrieved 18/05/2009.

  22. Cheung CM, Ponnusamy A, Anderton JG. Management of acute renal failure in the elderly patient: a clincians guide. Drug Aging. 2008;25(6):455–476.

    Article  CAS  Google Scholar 

  23. Bidani A, Churchill PC. Acute renal failure. Dis Mon. 1989;35:57–132.

    Article  CAS  PubMed  Google Scholar 

  24. Miura K,Goldstein RS,Morgan DG,Pasino DA, Hewitt WR, Hook JB, et al. Age-related differences in susceptibility to renal ischaemia in rats. Toxicol Appl Pharmacol. 1987;87:284–296.

    Article  CAS  PubMed  Google Scholar 

  25. Halfer M, Schelling G. Acute kidney failure. Physiopathology-clinical diagnosis-therapy. Anaesthetist 2000;49(4):349–52 .

    Google Scholar 

  26. Serdar MA, Kurt I,Ozcelik F, Urhan M, Ilgan S, Yenicesu M, et al. A practical approach to glomerular filtration rate measurements: Creatinine clearance estimation using cimetidine. Ann Clin Lab Sci. 2001;31:265–273.

    CAS  PubMed  Google Scholar 

  27. Urakami Y, Kimura N, Okuda M, Inui K. Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharm Res. 2004;21:976–981.

    Article  CAS  PubMed  Google Scholar 

  28. Warnock DG. Towards a Definition and Classification of Acute kiney injury. Editorial. J Am Soc Nephrol. 2005;16:3149–50.

    Article  PubMed  Google Scholar 

  29. Macias-Nunez JF, Lopez Novoa JM, Mariinez-Maldonado M. Acute renal failure in the aged. Semin Nephol. 1006;16:330–338.

    Google Scholar 

  30. Rainfray M, Richard-Harston S, Salles-Montaudon N, Emeriau JP. Effects of aging on kidney function and implications for medical practice. Presse Med. 200;29(24):1373–8.

    Google Scholar 

  31. Brown MA,Trew PA, Smart RC. A simple aid to diagnosis of oliguria. Aust NZ J Med. 1983;13(6):608–121.

    Article  CAS  Google Scholar 

  32. Miller TR. Anderson RJ, Linas SL, Henrich WL, Berns AS, Gabow OA, et al. Urinary diagnostics indices in acute renal failure: a prospective study. Ann Intern Med. 1978;89: 47–50.

    Article  CAS  PubMed  Google Scholar 

  33. Heget-Rosenthal S, Marggraf G, Husing J, Goring F, Pietruck F, Jakob HG, et al. Early detection of acute renal failure by serum Cystatin C .Kidney Int. 2004;46:1115–1122.

    Article  Google Scholar 

  34. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV. A novel biomarker for human renal proximal tubular injury. Kidney Int. 2002;62:237–244.

    Article  CAS  PubMed  Google Scholar 

  35. Mishra J, Dent C, Tarabishi R, Mitsnofes MM, Ma Q, Kelly C,et al. Neutrophil gelatinase –associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005;365:121–1238.

    Article  Google Scholar 

  36. Waikar SS, Lin KD, Chertow GM. Diagnosis, epidemiology and outcomes of acute kidney injury. CJASN. 2008;3(2):844–861.

    Article  PubMed  Google Scholar 

  37. Villa P, Jemenez M, Soriano MC, Manzanares J, Casanova SP. Serum cystatin C concentration as a marker of acutre renal dysfunction in critically ill patients. Crit Care. 2005;9:R139-R143.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Mazui-Sunko B, Zarkovic N, Vrkic N, Antoljak N, Bekavac BM, Nikolc Heitzler V, et al. Pro-atrial natriuretic peptide (1-98) but not cystatin C is predictive for occurrence of acute renal insufficiency in critically ill septic patients. Nephron Clin Pract 2004;97:C103-C107.

    Article  Google Scholar 

  39. Rabito C, Halpern Elkan F, Scott James, Tolkoff-Rubin, Nina. Et al. Accurate fast and convenient measurement of glmrerular filtration rate in potential renal transplant donor. Transplantation. 2010;90(5):510–7.

    Article  PubMed  Google Scholar 

  40. Kohli HS, Bhaskaran MC, Muthukumar T, Thennarasu K, Sud K, Jha V, et al, Treatment –related acute renal failure in the elderly: a hospital based prospective study. Nephrol Dial Transplant. 2000;15:212–217.

    Article  CAS  PubMed  Google Scholar 

  41. Ramao Junior JE, Halashi AR, Vidonho Junior AF. Et al. Causes and prognosis of acute renal failure in the elderly patients. Rev Assoc Med Bras. 2000;46(3):212–7 .

    Google Scholar 

  42. Schmitt R, Cantley LG. The impact of aging on kidney repair. Am J Physiol Renal Physiol. 2008;294: F1265-F1272.

    Article  CAS  PubMed  Google Scholar 

  43. Brovida C. Acute renal failure: from emergency to recovery. Acute Renal Failure-WSAVA. 2003. Congress.

    Google Scholar 

  44. Varier M, Fisher R, Osterman M. Acute kidney injury-An update. EMJ Nephrol. 2015;3(11):75–82.

    Google Scholar 

  45. Bagshaw SM. Acute kidney injury care bundles. Nephron. 2015;131:247–251.

    Article  PubMed  Google Scholar 

  46. Kerr M, Bedford M, Matthews B, O’Donoghue D. The economc impact of acute kidney injury in England. Nephrol Dial Transplant. 201;29(7):1362–8.

    Google Scholar 

  47. Levy ED, Viscoli CM, Horwitz RI. Effet of acute renal failure on mortality. A cohort analysis. JAMA. 1996;275(19):1489–1494.

    Article  CAS  PubMed  Google Scholar 

  48. Vivino G, Antornelli M, Moro ML, Cottini F, Conti G, Bufi M, et al. Risk factors for acute renal failure from trauma patents. Intensive Care Med. 1998;24(8):808–84.

    Article  CAS  PubMed  Google Scholar 

  49. Baretti P, Soares VA. Acute renal failure: clinical outcomes and causes of death. Renal Fail. 1997;19(2):253–57.

    Article  Google Scholar 

  50. Guly M,Turney JH. Post-traumatic acute renal failure 1956-1980. Clin Nephrol. 1990;34(2):79–83.

    CAS  PubMed  Google Scholar 

  51. Bullock ML, Umen AJ, Fenkelstein M, Kran WK. The assessment of risk factors in 462 patients with acute renal failure. Am J Kid Dis. 1985;5(2):97–103.

    Article  CAS  PubMed  Google Scholar 

  52. Gormick CC Jr, Kjellstrand CM.Acute renal failure complicating by aortic sneurysm. Surgery Nephron.1983;35(3):14–157.

    Google Scholar 

  53. Bedford M, Stevens E, Wheeler, TWK, Farmer, CKT. What is the real impact of Acute kidney injury? BMC Nephrology. 2014. https://doi.org/10.1186/1471.2369-15-95.

  54. Brivet FG, Kleinknecht DJ, Loirat P, Landias PJ. Acute renal failure in intensive care units- causes, oucome, and prognostic factors of hospital mortality; a propective multicentre study. French Study Group on Acute Renal Failure. Crit Care Med. 1996;24(2):192–8.

    Article  CAS  PubMed  Google Scholar 

  55. Chawla LS, Amdur RI, Amodeo S, Kimmel PL, Palant CE. The severity of acute kidney injury predicts progression to chronic kidney disease. Kidny Int. 2011;79:1361–1369.

    Article  Google Scholar 

  56. Ishani A, Xue JL, Himmelfarob J, Eggers PW, Kimmel M, Malitoris BA, et al. Acute kidney injury increases risk of end stage renal disease among elderly. J Am Soc Nephol. 2009;20(1):223–228.

    Article  Google Scholar 

  57. Hobson C, Ozrazgot-Baslanti T, Kuxhausen A, Thottakkara P, Efron PA, Moore FA, et al. Cost of mortality estimated with post-opeative acute kidney injury. Ann Surg. 2015;261:1207–1214.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Ali T, Khan I, Simpson W, Prescott G, Townend J, Smith W, Mcleod A. Incidence and oucomes in acut kidney injury: A comprehensive population-based study. J Am Soc Nephrology. 2007;18(4):1292–1298.

    Article  CAS  Google Scholar 

  59. Chertow GM, Soroko SH, Paganini EP, Cho K, Himmelfarb J, Ikizler TA, Mehta RL. et al. Mortality after acute renal failure: models for prognostic stratification and rik adjustments. Kidney Int. 2006;70(6):1120–1126.

    Article  CAS  PubMed  Google Scholar 

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Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2018). Acute Kidney Injury. In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-33434-9_33

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  • DOI: https://doi.org/10.1007/978-3-319-33434-9_33

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