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Chromophobe Renal Cell Carcinoma, Cytological Findings

  • Reference work entry
  • First Online:
Cytopathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 86 Accesses

Synonyms

Chromophobic renal cell carcinoma

Definition

The meaning of the term chromophobe carcinoma is that of a tumor that has phobia of color (chromo). When stained with the normal dyes (hematoxylin/eosin), it does not stain readily and thus appears paler under the microscope. Chromophobe renal carcinoma is a rare subtype of Renal cell carcinoma (RCC) with a better prognosis than clear cell carcinoma with many similarities to the intercalated cells of the collecting ducts, which seem to be the cell origin.

Clinical Features

  • Incidence

    Chromophobe renal carcinoma accounts for 4–6% of all renal carcinomas.

  • Age

    It affects mainly patients in the sixth decade of life. Presentation in tuberous sclerosis or in Birt-Hogg-Dubé Syndrome clinical set occurs earlier, affecting younger patients.

  • Sex

    Incidence of chromophobe renal cell carcinoma is similar in both men and women.

  • Site

    Kidney.

  • Treatment

    Partial nephrectomy is the usual procedure. Overexpression of CD117 on cellular membranes of...

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References and Further Reading

  • Amin, M. B., Paner, G. P., Alvarado-Cabrero, I., Young, A. N., Stricker, H. J., Lyles, R. H., & Moch, H. (2008). Chromophobe renal cell carcinoma: Histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases. The American Journal of Surgical Pathology, 32, 1822–1834.

    Article  PubMed  Google Scholar 

  • Beata, A., Wiatrowska, B. A., & Zakowski, M. F. (1999). Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma. Comparison of cytomorphologic features. Cancer Cytopathology, 87, 161–167.

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  • Geisinger, K. R., Stanley, M. W., Raab, S. S., Silverman, J. F., & Abati, A. (2004). Modern cytopathology (pp. 586–618). Philadelphia: Churchill Livingstone.

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  • Granter, S., & Renshaw, A. A. (1997). Fine-needle aspiration biopsy of chromophobe renal cell carcinoma. Analysis of six cases. Cancer Cytopathology, 81, 122–128.

    Article  CAS  PubMed  Google Scholar 

  • Jones, T. D., Eble, J. N., & Cheng, L. (2005). Application of molecular diagnostic techniques to renal epithelial neoplasms. Clinics in Laboratory Medicine, 25, 279–303.

    Article  PubMed  Google Scholar 

  • Stec, R., Grala, B., Mączewski, M., Bodnar, L., & Szczylik, C. (2009). Chromophobe renal cell cancer – Review of the literature and potential methods of treating metastatic disease. Journal of Experimental & Clinical Cancer Research, 28, 134.

    Article  CAS  Google Scholar 

  • Tejerina, E., González-Peramato, P., Jiménez-Heffernan, J. A., Vicandi, B., Serrano, A., López-Ferrer, P., & Viguer, J. M. (2009). Cytological features of chromophobe renal cell carcinoma, classic type. A report of nine cases. Cytopathology, 20, 44–49.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Hospital S João, Alameda Prof. Hernâni Monteiro, Al. Hernani Monteiro/4200 Porto, Porto, Portugal

    Helena Barroca

Authors
  1. Helena Barroca
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Corresponding author

Correspondence to Helena Barroca .

Editor information

Editors and Affiliations

  1. Laboratoire national de santé, Luxembourg City, Luxembourg

    Fernando Schmitt

  2. Medical Faculty of Porto University and IPATIMUP, Porto, Portugal

    Fernando Schmitt

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Barroca, H. (2017). Chromophobe Renal Cell Carcinoma, Cytological Findings. In: Schmitt, F. (eds) Cytopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-33286-4_847

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  • DOI: https://doi.org/10.1007/978-3-319-33286-4_847

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33285-7

  • Online ISBN: 978-3-319-33286-4

  • eBook Packages: MedicineReference Module Medicine

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