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Ex Vivo Perfusion

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Contemporary Heart Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

  • 111 Accesses

Abstract

Constant increases in the number of patients being listed for transplant and decreasing numbers of high-quality standard heart donors have placed a strain on heart transplant programs around the world. Efforts to increase the number of available donors with increased organ sharing and donor recruitment and use of extended criteria donors have had only modest effect at supplying needed organs. Because of these challenges, there has been a revival in interest in machine perfusion strategies to increase the use of marginal organs and improve the quality of organs when logistics demand long-distance organ procurement and to therapeutically intervene to improve organ quality. From early conceptual beginnings to the future potential of the therapy, this manuscript covers the evolution of ex vivo machine perfusion for support of heart transplantation.

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Authors and Affiliations

  1. Division of Cardiothoracic Surgery, University of Wisconsin, Madison, WI, USA

    Jason W. Smith & Amy Fiedler

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  1. Jason W. Smith
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  2. Amy Fiedler
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Correspondence to Jason W. Smith .

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Editors and Affiliations

  1. AdventHealth Transplant Institute, Orlando, FL, USA

    Linda Bogar

  2. Division of Cardiology, University of Washington, Seattle, WA, USA

    April Stempien-Otero

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Smith, J.W., Fiedler, A. (2020). Ex Vivo Perfusion. In: Bogar, L., Stempien-Otero, A. (eds) Contemporary Heart Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-33280-2_12-1

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  • DOI: https://doi.org/10.1007/978-3-319-33280-2_12-1

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  • Print ISBN: 978-3-319-33280-2

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