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Osteoarthritis

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Geriatric Diseases

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Abstract

Osteoarthritis (OA) is the most common age-related joint disease throughout the world and symptomatic OA is a leading cause of disability among elders. Currently, there is increasing realization that OA affects all the joint tissues. These include the synovium, meniscal pathology, bone marrow lesions, and subchondral bone. OA was thought to be a noninflammatory condition, but now it is evident that this is not so and there is evidence linking local inflammation with pain measured as synovitis/effusion. The present review will highlight the causation and pathogenesis of the disease.

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References

  1. Bagge E, Bjelli A, Edin S and Svanborg A. Osteoarhritis in the elderly: clinical and radiological findings in 78 and 85 years old. AmRheum Dis. 1991;50:535–539.

    Google Scholar 

  2. Felson DT. The course of osteoarthrits and factors that affect it. Rheum Dis Clin North Am. 1993;19:607–15.

    CAS  PubMed  Google Scholar 

  3. March LM, Bagga H. Epidemiology of osteoarthritis in Australia. MJA. 2004;180(5 Suppl) S6-S10.

    PubMed  Google Scholar 

  4. Arthritis Foundation of Australia: Access Economics Report 2001. quoted by March and Bagga, 2004.

    Google Scholar 

  5. National health survey. Canberra 1995: Australian Bureau of Statistics,1996.

    Google Scholar 

  6. Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51(2): 249–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Malfait AM. Osteoarthritis year in review 2015: biology. OsteoarthritisCartilage 2016;24(1):21–6.

    CAS  Google Scholar 

  8. Jones G. What’s new in osteoarthritis pathogenesis? Int Med J. https://doi.org/10.1111/imj.2763

  9. Zanetti E, Bruder E, Romero J, Hodler J. Bone marrpow edema pattern in osteoarthritic knees:correlation between MR imaging and histologic findngs. Radiology. 2000;215:835–840.

    Article  CAS  PubMed  Google Scholar 

  10. Wang Y, Teichtahl AJ, Cicuttini FM. Osteoarhritis year in review 2015: imaging. Ostreoarthritis Cartilage. 2016;24(1):49–57.

    Article  CAS  Google Scholar 

  11. Felson DT, Chaisson CE, Hill CL, Totteman SMS, Gale ME, Skinner KM, et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med. 2001;3(7):541–549.

    Article  Google Scholar 

  12. Hunter D, Zhang Y, Niu J, Gogns J, Amin S, LaVlley M, et al. Increase in bone marrow lesions is associate with cartilage loss: longitudinal MRI study in knee osteoarthritis. Arthritis Reum. 2006;54:1529–1535.

    Article  Google Scholar 

  13. Lo GH, Hunter DJ, Zhang Y, McLennan CE, LaVally MP, Kil DP, McLean RR, et al. Bone marrow lesions in the knee are asocited with increase local bone density. Arthritis Rheum. 2005;52:2811–2821.

    Article  Google Scholar 

  14. Taljanovic MS, Graham AR, Bjamin JB, Gmitro AF, Krupinski EA, Schwartz SA, et al. Bone marrow odema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings and histopathology. Skeletal Radiol. 2008;37(5):423–431.

    Article  PubMed  Google Scholar 

  15. Lowitz T, Museyko O, Bousson V, Laouisset L, Kalender WA, Laredo J-D, et al. Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT. Osteoarthrits Cartilate. 2013;21(7):957–964.

    Article  CAS  Google Scholar 

  16. Zhang Y, Nevitt M, Niu J, Lewis C Torner J, Guermazi A, et al. Fluctuation of knee pain and changes in bone marrow lesions, effusions and synovitis on magnetic tresonance imagig. Arthritis Rheum. 2011;63(3):691–699.

    Article  PubMed  Google Scholar 

  17. Yusuf E, Kortekaas MC, Watt I, Huizinga TW, Kloppenburg M. Do knee abnormalities visulalse on MRI explain knee pain in knee osteoarthritis? A systematic review. Ann Rheum Dis. 01170(1):60–67.

    Google Scholar 

  18. Felson DT, McLaughlin S, Goggins J, LaValley MP, Gale ME, Totterman S,et al. Bone marrow oedema and its relation to progression of knee osteoarthritis. Ann Intern Med.2003;139(5Part1):330–336.

    Google Scholar 

  19. Felson DT, Parkes MJ, Marjanoic M, Callighan A, Gat T, Cootes M, et al. NBone marrow lesions in knee osteoarthritis changes in 6–12 weeks. Ostoarhritis Cartilage. 2012;20(12):1514–151.

    Article  CAS  Google Scholar 

  20. Baranyay FJ, Wang Y, Wiuka AE, Engish DR, Giles GG, Sullivan RO,et al. Assocition of bone marrow lesions with knee structures and risk factors for bone marrow lesions in the knees of clinically ealthy community –based adults. Semin Arthrits Rheum. 2007;37:112–18.

    Article  Google Scholar 

  21. Hunter DJ, Bowes MA, Eaton CB, Holmes AP, Mann H, Kwoh CK, et al. Can cartilage loss be detected in knee osteoarthritis (OA) patients with 3–6 months observation using advanced image analysis of 3T MRI ? Osteoarthrtis Cartilge. 2010;18(5):677–683.

    Article  CAS  Google Scholar 

  22. Hunter DJ, Gersteinfeld L, Bishop G, Davis AD, Mason ZD, Einhorn TA, et al. bone marrow lesios from osteoarthritis of knees are characterused by sclerotic bone thst is less well mineralized. Arthritis Res Ther. 2009;11>R11. https://doi.org/10.1186/ar2601.

  23. Jones G. Sources of pain in osteoarthritis: implications for therapy. Int J Clin Rheumatol 2013;8:335–46.

    Article  CAS  Google Scholar 

  24. Wessinghage D. Rheumatic Diseases. What would be your diagnosis. Ciba-Geigy Australia Limited.

    Google Scholar 

  25. Zhang Y, Niu J, Kelly-Hayes M, Chaisson CE,Aliaba LP, Felson DT. Prevalence of symptomatic hand osteoarthritis and its inpact on functional status among the elderly. The Framingham study. Am J Epidemiol 2002;156:1021–1027.

    Article  PubMed  Google Scholar 

  26. Manek NJ, Lane NE. Osteoarthritis: Current concepts in diagnosis and management. Am Fam Physician. 2001;61:1795–804.

    Google Scholar 

  27. Braun HJ, Gold GE. Diagnosi of osteoarthritis: Imagg. Bone. 2012;51(2):278–288.

    Article  PubMed  Google Scholar 

  28. Guemazi A, Roemer FW, Hyashi D, Imaging od osteoarthritis:update from a radiological perspective. Curr Opin Rheumatol. 2011;23:484–91.

    Article  Google Scholar 

  29. Aging for Health care Research Quality (AHRQ)-Managing Osteoarthritis-Research in Action. Issue 4. US. Department of Human & Health Services.www.ahrq.gov/research/oskoria/oskoria.htm.

  30. Suresh E. Recent advances in rheumatoid arthritis. Postgrad Med J. 2010; 86(1014):243–50.

    Article  PubMed  Google Scholar 

  31. National Center for Complimentary and Alternative Medicine. The NIH Glucosamine/ch=Chondroitn Arthritis Intervention Trial (GAIT). Pain Palliat Care Pharmacother. 2008:22:39–43.

    Article  Google Scholar 

  32. Hochberg MC, Clegg DO. Potential effects of chondrotin sulfate on swelling : a GAIT report. Osteoarthritis cartilage. 2008;16:522–4 .

    Article  Google Scholar 

  33. Clegg DO, Riva DJ, Harris CL, Klein MA, O’Dell JR, Hoper MM, et al. Glucosamine or chondroitin sulphate and the two combined for painful knee osteoarthritis. N Engl J Med. 2006;354:795–806.

    Article  CAS  PubMed  Google Scholar 

  34. Bruyere O, Regnister JY. Glucosamine and chondroitin sulphate as therapeutic agents for knee and hip osteoarthritis,. Drugs Aging. 2007;24:573–80 .

    Article  CAS  PubMed  Google Scholar 

  35. Breedveld FC. Osteoarthritis-the impact of aserious disease. Rheumatology. 2004;43(Suppl 1):i4-i8.

    Article  PubMed  Google Scholar 

  36. Laslett LL, Quin SJ, Winzenberg TM, Sanderson K, Cieuttini F, Jones G. Aprospective study of the impact of musculoskeltal pain and radiographic abnormalities on health related quality of life in community dwelling older people. BMC Musculoskelet Disord. 2012.13:188. https://doi.org/10.1186/147-2474-1-168.

    Article  Google Scholar 

  37. Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh AK, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Arthritis Rheum. 2008;58(1):15–25.

    Article  PubMed  Google Scholar 

  38. Marks R, Allegrante JP. Comorbid disease profiles of adults with end stage hip osteoarthritis. Med Sci Monit. 2002;28:CR305–9.

    Google Scholar 

  39. Gabriel SE, Crowson CS, O’Fallon WM. Comorbidity in arthritis. J Rheumatol. 1999;26:2475–9.

    CAS  PubMed  Google Scholar 

  40. Ling SM, Bathon JM. Osteoarthrits in older adults. J Am Geriatr Soc. 1998;46:216–2520.

    Article  CAS  PubMed  Google Scholar 

  41. Singh G, Miller JD, Lee FH, Pettitt D, Russel MW. Prevalence of cardiovascular risk factors among US adults with self-reported osteoarthritis: data from the Third National Health and Nutrition Examination Survey. Am J Manag Care. 2002;8:S383–91.

    Google Scholar 

  42. Verbrugge LM, Lepkowski JM, Konkol LL. Levels of disability among US adults with arthritis. J Gerontol. 1991;46(2):S71–83.

    Article  CAS  PubMed  Google Scholar 

  43. Sheehy C, Murphy E, Barry M. Depression in arthritis-underscoring the problem. Rheumatology (Oxford). 2006;45:1325–1327.

    Article  CAS  PubMed  Google Scholar 

  44. Murphy LB, Sacks JJ, Brady TJ, Hootman JM, Chaoman DP. Anxiety and depression among US adults with arthritis: prevalence and correlates. Arthritis Care Res. 2012;64(7):968–976.

    Google Scholar 

  45. Briggs A, Scott E, Steele K. Impact of osteoarthritis and analgesic treatment on quality of life of an elderly population. Ann Pharmacother. 1999; 33(11):1154–9.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Sydney Medical School (Westmead), The University of Sydney, 20 Panaview Crescent, 2151, North Rocks, NSW, Australia

    Nages Nagaratnam & Kujan Nagaratnam

  2. Rehabilitation and Aged Care Service, Blacktown-Mt Druitt Hospital, 2148, Sydney, NSW, Australia

    Gary Cheuk

Authors
  1. Nages Nagaratnam
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  2. Kujan Nagaratnam
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  3. Gary Cheuk
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Correspondence to Nages Nagaratnam .

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© 2017 Springer International Publishing AG

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Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2017). Osteoarthritis. In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-32700-6_58-1

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  • DOI: https://doi.org/10.1007/978-3-319-32700-6_58-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32700-6

  • Online ISBN: 978-3-319-32700-6

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