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Cerebral Gliomas

  • Justin Cohen
  • Sergui Bannykh
  • Joshua Breunig
  • Moise Danielpour
Living reference work entry

Abstract

The majority of hemispheric gliomas in children are low-grade non-infiltrating entities (Pollack 1994). Many features distinguish these tumors from their adult counterparts including histologic appearance, distribution, incidence, and biological behavior. Owing to advances in genetic technology, we have seen dramatic increase in understanding the role of causative genetic mutations and dependence on developmental pathways in oncogenesis and maintenance of pediatric gliomas. In the coming years, continued advancement in understanding of and age-related features in biological behavior, including development and maintenance of these tumors, may lead to development of more rational treatments offering greater survival with decreased morbidity (Schwartzentruber et al. 2012; Zhang et al. 2013; Rohle et al. 2013; Parsons et al. 2008; Frattini et al. 2013; Verhaak et al. 2010; Baker et al. 2015).

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Justin Cohen
    • 1
  • Sergui Bannykh
    • 2
  • Joshua Breunig
    • 3
  • Moise Danielpour
    • 1
  1. 1.Department of NeurosurgeryCedars Sinai Medical CenterLos AngelesUSA
  2. 2.Department of PathologyCedars Sinai Medical CenterLos AngelesUSA
  3. 3.Department of Biomedical SciencesRegenerative Medicine Institute, Cedars Sinai Medical CenterLos AngelesUSA

Section editors and affiliations

  • James Thomas Rutka
    • 1
  1. 1.The Arthur and Sonia Labatt Brain Tumour Research CentreThe Hospital for Sick Children, The University of TorontoTorontoUSA

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