Skip to main content
SpringerLink
Log in

Choroid Plexus Tumors

  • Living reference work entry
  • First Online:
Textbook of Pediatric Neurosurgery

  • 139 Accesses

Abstract

Choroid plexus tumors are rare, predominantly intraventricular tumors that occur in children. Pathologically they are classified as choroid plexus papillomas that are benign and almost always treated by surgery alone, choroid plexus carcinomas that are malignant aggressive tumors, and the intermediary atypical choroid plexus papillomas. There is a strong association between choroid plexus carcinoma and TP53 mutations. These tumors present with hydrocephalus or macrocephaly. They are challenging surgically as their high vascularity often leads to significant blood loss in small children with a low circulating blood volume. This can be mitigated by preoperative embolization or neoadjuvant chemotherapy. Maximal safe surgical resection is central to effective treatment, and most multivariate analyses have underlined the importance of gross total resection. Second-look surgery has also been associated with improved prognosis. Choroid plexus carcinomas also require adjuvant chemotherapy and consideration of radiotherapy. However, the role of radiotherapy is not clear; in view of the large size of these tumors, the young age of most patients, and the relatively high frequency of underlying tumor-predisposing conditions such as Li-Fraumeni syndrome, radiotherapy should be avoided in a high proportion of cases. Overall survival in most series of choroid plexus carcinomas has been poor.

The rarity of these tumors has made the development of clear guidelines challenging. Most case series are small. Retrospective analyses from epidemiological databases or meta-analyses from published series are compromised by incomplete individual data or multiple representations of the same patients. The value of central discussion of these patients with a specialist choroid plexus tumor interest group cannot be overemphasized. Recent studies have improved understanding of the genetic landscape of these tumors and should hopefully lead on to clinical trials of targeted agents in the near future.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Altshuler C, Haley K, Dhall G, Vasquez L, Gardner SL, Stanek J et al (2016) Decreased morbidity and mortality of autologous hematopoietic transplants for children with malignant central nervous system tumors: the “head start” trials, 1991–2009. Bone Marrow Transplant 51(7):945–948

    Article  CAS  PubMed  Google Scholar 

  • Anguilar D, Martín JM, Aneiros J, Arjona V, Lara JL, Nogales F (1983) The fine structure of choroid plexus carcinoma. Histopathology 7(6):939–946

    Article  CAS  PubMed  Google Scholar 

  • Anselem O, Mezzetta L, Grangé G, Zerah M, Benard C, Marcou V et al (2011) Fetal tumors of the choroid plexus: is differential diagnosis between papilloma and carcinoma possible? Ultrasound Obstet Gynecol 38(2):229–232

    Article  CAS  PubMed  Google Scholar 

  • Bahar M, Kordes U, Tekautz T, Wolff J (2015) Radiation therapy for choroid plexus carcinoma patients with Li-Fraumeni syndrome: advantageous or detrimental? Anticancer Res 35(5):3013–3017

    PubMed  Google Scholar 

  • Bahar M, Hashem H, Tekautz T, Worley S, Tang A, de Blank P et al (2017) Choroid plexus tumors in adult and pediatric populations: the Cleveland Clinic and university hospitals experience. J Neuro-Oncol 132(3):427–432

    Article  Google Scholar 

  • Bauchet L, Rigau V, Mathieu-Daudé H, Fabbro-Peray P, Palenzuela G, Figarella-Branger D et al (2009) Clinical epidemiology for childhood primary central nervous system tumors. J Neuro-Oncol 92(1):87–98

    Article  Google Scholar 

  • Berger C, THIESSE P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E (1998) Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery 42(3):470–475

    Article  CAS  PubMed  Google Scholar 

  • Bergsagel DJ, Finegold MJ, Butel JS, Kupsky WJ, Garcea RL (1992) DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. N Engl J Med 326(15):988–993

    Article  CAS  PubMed  Google Scholar 

  • Bettegowda C, Adogwa O, Mehta V, Chaichana KL, Weingart J, Carson BS et al (2012) Treatment of choroid plexus tumors: a 20-year single institutional experience. J Neurosurg Pediatr 10(5):398–405

    Article  PubMed  PubMed Central  Google Scholar 

  • Boström A, Boström JP, von Lehe M, Kandenwein JA, Schramm J, Simon M (2011) Surgical treatment of choroid plexus tumors. Acta Neurochir 153(2):371–376

    Article  PubMed  Google Scholar 

  • Carlotti CG, Salhia B, Weitzman S, Greenberg M, Dirks PB, Mason W et al (2002) Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children. Acta Neuropathol 103(1):1–10

    Article  CAS  PubMed  Google Scholar 

  • Chow E, Reardon DA, Shah AB, Jenkins JJ, Langston J, Heideman RL et al (1999a) Pediatric choroid plexus neoplasms. Int J Radiat Oncol Biol Phys 44(2):249–254

    Article  CAS  PubMed  Google Scholar 

  • Chow E, Jenkins JJ, Burger PC, Reardon DA, Langston JW, Sanford RA et al (1999b) Malignant evolution of choroid plexus papilloma. Pediatr Neurosurg 31(3):127–130

    Article  CAS  PubMed  Google Scholar 

  • Cikla U, Swanson KI, Tumturk A, Keser N, Uluc K, Cohen-Gadol A et al (2016) Microsurgical resection of tumors of the lateral and third ventricles: operative corridors for difficult-to-reach lesions. J Neuro-Oncol 130(2):331–340

    Article  Google Scholar 

  • Dangouloff-Ros V, Grevent D, Pagès M, Blauwblomme T, Calmon R, Elie C et al (2015) Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. AJNR Am J Neuroradiol 36(9):1786–1790

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dash C, Moorthy S, Garg K, Singh PK, Kumar A, Gurjar H et al (2019) Management of Choroid Plexus Tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg 121:e237–e245

    Article  PubMed  Google Scholar 

  • Dudley RWR, Torok MR, Gallegos D, Liu AK, Handler MH, Hankinson TC (2015) Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database. J Neuro-Oncol 121(1):201–207

    Article  Google Scholar 

  • Due-Tønnessen B, Helseth E, Skullerud K, Lundar T (2001) Choroid plexus tumors in children and young adults: report of 16 consecutive cases. Childs Nerv Syst 17(4–5):252–256

    Article  PubMed  Google Scholar 

  • Eisenberg HM, McComb JG, Lorenzo AV (1974) Cerebrospinal fluid overproduction and hydrocephalus associated with choroid plexus papilloma. J Neurosurg 40(3):381–385

    Article  CAS  PubMed  Google Scholar 

  • García-Lecea M, Kondrychyn I, Fong SH, Ye Z-R, Korzh V (2008) In vivo analysis of choroid plexus morphogenesis in zebrafish. PLoS One 3(9):e3090

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gonzalez KD, Noltner KA, Buzin CH, Gu D, Wen-Fong CY, Nguyen VQ et al (2009) Beyond Li Fraumeni syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol 27(8):1250–1256

    Article  CAS  PubMed  Google Scholar 

  • Gupta N (2003) Choroid plexus tumors in children. Neurosurg Clin N Am 14(4):621–631

    Article  PubMed  Google Scholar 

  • Haliasos N, Brew S, Robertson F, Hayward R, Thompson D, Chakraborty A (2013a) Preoperative embolisation of choroid plexus tumours in children: part I-does the reduction of perioperative blood loss affect the safety of subsequent surgery? Childs Nerv Syst 29(1):65–70

    Article  PubMed  Google Scholar 

  • Haliasos N, Brew S, Robertson F, Hayward R, Thompson D, Chakraborty A (2013b) Pre-operative embolisation of choroid plexus tumours in children. Part II. Observations on the effects on CSF production. Childs Nerv Syst 29(1):71–76

    Article  PubMed  Google Scholar 

  • Hasselblatt M, Böhm C, Tatenhorst L, Dinh V, Newrzella D, Keyvani K et al (2006) Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Am J Surg Pathol 30(1):66–74

    Article  PubMed  Google Scholar 

  • Hirsch JF, Sainte-Rose C (1991) A new surgical approach to subcortical lesions: balloon inflation and cortical gluing. Technical note. J Neurosurg 74(6):1014–1017

    Article  CAS  PubMed  Google Scholar 

  • Horská A, Ulug AM, Melhem ER, Filippi CG, Burger PC, Edgar MA et al (2001) Proton magnetic resonance spectroscopy of choroid plexus tumors in children. J Magn Reson Imaging 14(1):78–82

    Article  PubMed  Google Scholar 

  • Hosmann A, Hinker F, Dorfer C, Slavc I, Haberler C, Dieckmann K et al (2019) Management of choroid plexus tumors-an institutional experience. Acta Neurochir 161(4):745–754

    Article  PubMed  Google Scholar 

  • Jeibmann A, Hasselblatt M, Gerß J, Wrede B, Egensperger R, Beschorner R et al (2006) Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol 65(11):1069–1073

    Article  PubMed  Google Scholar 

  • Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M (2007) Malignant progression in choroid plexus papillomas. J Neurosurg 107(3 Suppl):199–202

    PubMed  Google Scholar 

  • Kennedy BC, Cloney MB, Anderson RCE, Feldstein NA (2015) Superior parietal lobule approach for choroid plexus papillomas without preoperative embolization in very young children. J Neurosurg Pediatr 16(1):101–106

    Article  PubMed  Google Scholar 

  • Kim J-H, Jang W-Y, Duy Khuong LN, Jung TY, Moon KS, Kim I-Y et al (2018) Selection of surgical approach for trigonal Meningiomas in consideration of visual outcome. World Neurosurg 118:e436–e442

    Article  PubMed  Google Scholar 

  • Koh EJ, Wang K-C, Phi JH, Lee JY, Choi JW, Park S-H et al (2014) Clinical outcome of pediatric choroid plexus tumors: retrospective analysis from a single institute. Childs Nerv Syst 30(2):217–225

    Article  PubMed  Google Scholar 

  • Koos B, Paulsson J, Jarvius M, Sanchez BC, Wrede B, Mertsch S et al (2009) Platelet-derived growth factor receptor expression and activation in choroid plexus tumors. Am J Pathol 175(4):1631–1637

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krieger MD, Panigrahy A, McComb JG, Nelson MD, Liu X, Gonzalez-Gomez I et al (2005) Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus 18(6A):E4

    PubMed  Google Scholar 

  • Krishnan S, Brown PD, Scheithauer BW, Ebersold MJ, Hammack JE, Buckner JC (2004) Choroid plexus papillomas: a single institutional experience. J Neuro-Oncol 68(1):49–55

    Article  Google Scholar 

  • Lafay-Cousin L, Keene D, Carret A-S, Fryer C, Brossard J, Crooks B et al (2011) Choroid plexus tumors in children less than 36 months: the Canadian pediatric brain tumor consortium (CPBTC) experience. Childs Nerv Syst 27(2):259–264

    Article  PubMed  Google Scholar 

  • Lam S, Lin Y, Cherian J, Qadri U, Harris DA, Melkonian S et al (2013) Choroid plexus tumors in children: a population-based study. Pediatr Neurosurg 49(6):331–338

    Article  PubMed  Google Scholar 

  • Longatti P, Basaldella L, Orvieto E, Dei Tos A, Martinuzzi A (2006) Aquaporin(s) expression in choroid plexus tumours. Pediatr Neurosurg 42(4):228–233

    Article  PubMed  Google Scholar 

  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114(2):97–109

    Article  PubMed  PubMed Central  Google Scholar 

  • Mallick S, Benson R, Melgandi W, Rath GK (2017) Effect of surgery, adjuvant therapy, and other prognostic factors on choroid plexus carcinoma: a systematic review and individual patient data analysis. Int J Radiat Oncol Biol Phys 99(5):1199–1206

    Article  PubMed  Google Scholar 

  • Matson DD, Crofton FD (1960) Papilloma of the choroid plexus in childhood. J Neurosurg 17:1002–1027

    Article  CAS  PubMed  Google Scholar 

  • Mazloom A, Wolff JE, Paulino AC (2010) The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. Int J Radiat Oncol Biol Phys 78(1):79–84

    Article  PubMed  Google Scholar 

  • McEvoy AW, Harding BN, Phipps KP, Ellison DW, Elsmore AJ, Thompson D et al (2000) Management of choroid plexus tumours in children: 20 years experience at a single neurosurgical Centre. Pediatr Neurosurg 32(4):192–199

    Article  CAS  PubMed  Google Scholar 

  • Meng H, Feng H, Zhang L, Wang J (2011) Endoscopic removal of a cystic choroid plexus papilloma of the third ventricle: a case report and review of the literature. Clin Neurol Neurosurg 113(7):582–585

    Article  PubMed  Google Scholar 

  • Merino DM, Shlien A, Villani A, Pienkowska M, Mack S, Ramaswamy V et al (2015) Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res 21(1):184–192

    Article  CAS  PubMed  Google Scholar 

  • Nagib MG, O’Fallon MT (2000) Lateral ventricle choroid plexus papilloma in childhood: management and complications. Surg Neurol 54(5):366–372

    Article  CAS  PubMed  Google Scholar 

  • Ogiwara H, DiPatri AJ, Alden TD, Bowman RM, Tomita T (2012) Choroid plexus tumors in pediatric patients. Br J Neurosurg 26(1):32–37

    Article  PubMed  Google Scholar 

  • Ohgaki H, Huang H, Haltia M, Vainio H, Kleihues P (2000) More about: cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst 92(6):495–497

    Article  CAS  PubMed  Google Scholar 

  • Olivier M, Goldgar DE, Sodha N, Ohgaki H, Kleihues P, Hainaut P et al (2003) Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. Cancer Res 63(20):6643–6650

    CAS  PubMed  Google Scholar 

  • Otten ML, Riina HA, Gobin YP, Souweidane MM (2006) Preoperative embolization in the treatment of choroid plexus papilloma in an infant. Case report. J Neurosurg 104(6 Suppl):419–421

    PubMed  Google Scholar 

  • Pencalet P, Sainte-Rose C, Lellouch-Tubiana A, Kalifa C, Brunelle F, Sgouros S et al (1998) Papillomas and carcinomas of the choroid plexus in children. J Neurosurg 88(3):521–528

    Article  CAS  PubMed  Google Scholar 

  • Pollack IF, Schor NF, Martinez AJ, Towbin R (1995) Bobble-head doll syndrome and drop attacks in a child with a cystic choroid plexus papilloma of the third ventricle. Case report. J Neurosurg 83(4):729–732

    Article  CAS  PubMed  Google Scholar 

  • Reddy D, Gunnarsson T, Scheinemann K, Provias JP, Singh SK (2011) Combined staged endoscopic and microsurgical approach of a third ventricular choroid plexus papilloma in an infant. Minim Invasive Neurosurg 54(5–6):264–267

    CAS  PubMed  Google Scholar 

  • Roldán PP, López VS-M, La Madrid AM, Cruz O, Muchart J, Thomas C et al (2019) Vanishing diffuse leptomeningeal contrast enhancement in an infant with choroid plexus papilloma. Acta Neurochir (Wien) 161(2):351–354

    Article  Google Scholar 

  • Ruland V, Hartung S, Kordes U, Wolff JE, Paulus W, Hasselblatt M (2014) Methylation of the hTERT promoter is frequent in choroid plexus tumors but not of independent prognostic value. J Neuro-Oncol 119(1):215–216

    Article  Google Scholar 

  • Safaee M, Oh MC, Bloch O, Sun MZ, Kaur G, Auguste KI et al (2013) Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis. Neuro-Oncology 15(3):255–267

    Article  CAS  PubMed  Google Scholar 

  • Samuel N, Wilson G, Lemire M, Id Said B, Lou Y, Li W et al (2016) Genome-wide DNA methylation analysis reveals epigenetic dysregulation of MicroRNA-34A in TP53-associated Cancer susceptibility. J Clin Oncol 34(30):3697–3704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Santos MM, Souweidane MM (2015) Purely endoscopic resection of a choroid plexus papilloma of the third ventricle: case report. J Neurosurg Pediatr 16(1):54–57

    Article  PubMed  Google Scholar 

  • Scala M, Morana G, Milanaccio C, Pavanello M, Nozza P, Garrè ML (2017) Atypical choroid plexus papilloma: spontaneous resolution of diffuse leptomeningeal contrast enhancement after primary tumor removal in 2 pediatric cases. J Neurosurg Pediatr 20(3):284–288

    Article  PubMed  Google Scholar 

  • Schneider C, Kamaly-Asl I, Ramaswamy V, Lafay-Cousin L, Kulkarni AV, Rutka JT et al (2015) Neoadjuvant chemotherapy reduces blood loss during the resection of pediatric choroid plexus carcinomas. J Neurosurg Pediatr 16(2):126–133

    Article  PubMed  Google Scholar 

  • Siegfried A, Morin S, Munzer C, Delisle MB, Gambart M, Puget S et al (2017) A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neuro-Oncol 135(1):151–160

    Article  CAS  Google Scholar 

  • Slater L-A, Hoffman C, Drake J, Krings T (2016) Pre-operative embolization of a choroid plexus carcinoma: review of the vascular anatomy. Childs Nerv Syst 32(3):541–545

    Article  PubMed  Google Scholar 

  • Spector R, Keep RF, Robert Snodgrass S, Smith QR, Johanson CE (2015) A balanced view of choroid plexus structure and function: focus on adult humans. Exp Neurol 267:78–86

    Article  PubMed  Google Scholar 

  • Strojan P, Popović M, Surlan K, Jereb B (2004) Choroid plexus tumors: a review of 28-year experience. Neoplasma 51(4):306–312

    CAS  PubMed  Google Scholar 

  • Stuivenvolt M, Mandl E, Verheul J, Fleischeuer R, Tijssen CC (2012) Atypical transformation in sacral drop metastasis from posterior fossa choroid plexus papilloma. BMJ Case Rep 2012. https://doi.org/10.1136/bcr-01-2012-5681

    Google Scholar 

  • Sufianov AA, Gaibov SSK, Sufianov RA (2015) Endoscopic monoportal removal of a choroid plexus papilloma in the posterior third ventricle in a child. J Neurosurg Pediatr 16(1):107–111

    Article  PubMed  Google Scholar 

  • Sun MZ, Oh MC, Ivan ME, Kaur G, Safaee M, Kim JM et al (2014a) Current management of choroid plexus carcinomas. Neurosurg Rev 37(2):179–192. discussion 192

    Article  PubMed  Google Scholar 

  • Sun MZ, Ivan ME, Clark AJ, Oh MC, Delance AR, Oh T et al (2014b) Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neuro-Oncol 116(1):179–185

    Article  Google Scholar 

  • Sun MZ, Ivan ME, Oh MC, Delance AR, Clark AJ, Safaee M et al (2014c) Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. J Neuro-Oncol 120(2):353–360

    Article  Google Scholar 

  • Tabori U, Shlien A, Baskin B, Levitt S, Ray P, Alon N et al (2010) TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors. J Clin Oncol 28(12):1995–2001

    Article  CAS  PubMed  Google Scholar 

  • Thomas C, Ruland V, Kordes U, Hartung S, Capper D, Pietsch T et al (2015) Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic only in older children. Acta Neuropathol 129(6):925–927

    Article  PubMed  Google Scholar 

  • Thomas C, Sill M, Ruland V, Witten A, Hartung S, Kordes U et al (2016) Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro-Oncology 18(6):790–796

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tong Y, Merino D, Nimmervoll B, Gupta K, Wang Y-D, Finkelstein D et al (2015) Cross-species genomics identifies TAF12, NFYC, and RAD54L as choroid plexus carcinoma oncogenes. Cancer Cell 27(5):712–727

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Trivelato FP, Manzato LB, Rezende MT, Barroso PMC, Faleiro RM, Ulhôa AC (2012) Preoperative embolization of choroid plexus papilloma with Onyx via the anterior choroidal artery: technical note. Childs Nerv Syst 28(11):1955–1958

    Article  PubMed  Google Scholar 

  • van Wagenen WP (1930) Papillomas of the choroid plexus. Report of two cases, one with removal of tumor at operation and one with “seeding” of the tumor in the ventricular system. Arch Surg 20:199–231

    Article  Google Scholar 

  • Waldron JS, Tihan T (2003) Epidemiology and pathology of intraventricular tumors. Neurosurg Clin N Am 14(4):469–482

    Article  PubMed  Google Scholar 

  • Wang H-H, Luo C-B, Guo W-Y, Wu H-M, Lirng J-F, Wong T-T et al (2013) Preoperative embolization of hypervascular pediatric brain tumors: evaluation of technical safety and outcome. Childs Nerv Syst 29(11):2043–2049

    Article  PubMed  Google Scholar 

  • Whibley C, Pharoah PDP, Hollstein M (2009) p53 polymorphisms: cancer implications. Nat Rev Cancer 9(2):95–107

    Article  CAS  PubMed  Google Scholar 

  • Wind JJ, Bell RS, Bank WO, Myseros JS (2010) Treatment of third ventricular choroid plexus papilloma in an infant with embolization alone. J Neurosurg Pediatr 6(6):579–582

    Article  PubMed  Google Scholar 

  • Wolburg H, Paulus W (2010) Choroid plexus: biology and pathology. Acta Neuropathol 119(1):75–88

    Article  PubMed  Google Scholar 

  • Wolff JEA, Sajedi M, Brant R, Coppes MJ, Egeler RM (2002) Choroid plexus tumours. Br J Cancer 87(10):1086–1091

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wrede B, Liu P, Ater J, Wolff JEA (2005) Second surgery and the prognosis of choroid plexus carcinoma – results of a meta-analysis of individual cases. Anticancer Res 25(6C):4429–4433

    PubMed  Google Scholar 

  • Wrede B, Liu P, Wolff JEA (2007) Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neuro-Oncol 85(3):345–351

    Article  Google Scholar 

  • Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A et al (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neuro-Oncol 95(3):383–392

    Article  CAS  Google Scholar 

  • Zajac V, Kirchhoff T, Levy ER, Horsley SW, Miller A, Steichen-Gersdorf E et al (1997) Characterisation of X;17(q12;p13) translocation breakpoints in a female patient with hypomelanosis of Ito and choroid plexus papilloma. Eur J Hum Genet 5(2):61–68

    Article  CAS  PubMed  Google Scholar 

  • Zaky W, Finlay JL (2018) Pediatric choroid plexus carcinoma: biologically and clinically in need of new perspectives. Pediatr Blood Cancer 65(7):e27031

    Article  PubMed  Google Scholar 

  • Zaky W, Dhall G, Khatua S, Brown RJ, Ginn KF, Gardner SL et al (2015) Choroid plexus carcinoma in children: the head start experience. Pediatr Blood Cancer 62(5):784–789

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Great Ormond Street Hospital, London, UK

    Kristian Aquilina

Authors
  1. Kristian Aquilina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kristian Aquilina .

Editor information

Editors and Affiliations

  1. International Neuroscience Institute, Hannover, Germany

    Concezio Di Rocco

  2. Oakland Medical Center, Oakland, CA, USA

    Dachling Pang

  3. University of Toronto Hospital for Sick Children, Toronto, ON, Canada

    James T. Rutka

Section Editor information

  1. The Hospital for Sick Children, Toronto, ON, Canada

    James T Rutka

  2. Division of Neurosurgery, Hospital for Sick Children, Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada

    James T Rutka

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Crown

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Aquilina, K. (2019). Choroid Plexus Tumors. In: Di Rocco, C., Pang, D., Rutka, J. (eds) Textbook of Pediatric Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-31512-6_154-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31512-6_154-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31512-6

  • Online ISBN: 978-3-319-31512-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation