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Pediatric Hypertension pp 1–10Cite as

Hypertensive Models and Their Relevance to Pediatric Hypertension

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Abstract

Much of what we know about the physiology of blood pressure (BP) regulation and the pathogenesis and treatment of human hypertension has been derived from studies in other animal species. This chapter presents a variety of models of experimental hypertension with the intent of providing a background for the interested reader. Many models explore normal and abnormal physiology without genetic manipulation but rather with the use of surgery, infusion of medications, alterations in diet, and application of stressful conditions. In other models, inbreeding or genetic manipulation are used to produce increased (or decreased) BP. The many models available should be considered both for carrying out research and for evaluating published studies.

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  1. Pediatric Nephrology Unit, MassGeneral Hospital for Children at Massachusetts General Hospital (MGH), Harvard Medical School, Yawkey 6C, 55 Fruit Street, Boston, MA, 02114, USA

    Julie R. Ingelfinger

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  1. Julie R. Ingelfinger
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  1. Division of Nephrology, Seattle Children's Hospital, Seattle, Washington, USA

    Joseph Flynn

  2. Massachusetts General Hospital, Boston, Massachusetts, USA

    Julie R. Ingelfinger

  3. Arkansas Children's Hospital, University of Arkansas Medical Science, Little Rock, Arkansas, USA

    Karen Redwine

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Ingelfinger, J.R. (2017). Hypertensive Models and Their Relevance to Pediatric Hypertension. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31420-4_55-1

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  1. Latest

    Hypertensive Models and Their Relevance to Pediatric Hypertension
    Published:
    28 June 2022

    DOI: https://doi.org/10.1007/978-3-319-31420-4_55-2

  2. Original

    Hypertensive Models and Their Relevance to Pediatric Hypertension
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    19 April 2017

    DOI: https://doi.org/10.1007/978-3-319-31420-4_55-1

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