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Ions and Fluid Dynamics in Hypertension

Pediatric Hypertension

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Abstract

Ion transport is known to be involved in the genesis of hypertension and is utilized therapeutically. However, the mechanisms behind sodium flux that may lead to hypertension are not well understood. Target proteins of diuretic agents, monogenic forms of hypertension, and genetic disorders of renal salt wasting have all provided insight into these pathways. In this chapter, we review some of these channels and their relevance to human hypertension. We explore the role of the cytoskeletal protein adducin in the regulation of sodium transport. We examine the function of the osmotically inactive sodium compartment and its regulation, and hormonal alterations affecting this compartment in salt-sensitive hypertension.

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Authors and Affiliations

  1. Division of Nephrology, Boston Children’s Hospital, 300 Longwood Avenue, HU-319, 02115, Boston, MA, USA

    Avram Z. Traum

  2. Department of Pediatrics, Harvard Medical School, Boston, MA, USA

    Avram Z. Traum

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Editors and Affiliations

  1. Division of Nephrology, Seattle Children's Hospital, Seattle, Washington, USA

    Joseph Flynn

  2. Massachusetts General Hospital, Boston, Massachusetts, USA

    Julie R. Ingelfinger

  3. Arkansas Children's Hospital, University of Arkansas Medical Science, Little Rock, Arkansas, USA

    Karen Redwine

Section Editor information

  1. Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Harvard Medical School, Fruit St. 55, 02114, Boston, MA, USA

    Julie R. Ingelfinger M.D.

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Traum, A.Z. (2017). Ions and Fluid Dynamics in Hypertension. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31420-4_4-1

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  • DOI: https://doi.org/10.1007/978-3-319-31420-4_4-1

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  1. Latest

    Ions and Fluid Dynamics in Hypertension
    Published:
    02 June 2022

    DOI: https://doi.org/10.1007/978-3-319-31420-4_4-2

  2. Original

    Ions and Fluid Dynamics in Hypertension
    Published:
    11 April 2017

    DOI: https://doi.org/10.1007/978-3-319-31420-4_4-1

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