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Mechanisms of Tumor Angiogenesis

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Tumor Angiogenesis

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Abstract

Tumor angiogenesis, the process by which blood vessels penetrate and grow in the tumor microenvironment, is essential for oxygen and nutrient supply and hence constitutes a key player for the survival of solid neoplasms. Different mechanisms of angiogenesis are developed during tumor progression such as vasculogenesis, sprouting angiogenesis, intussusception, and vasculogenic mimicry. The transition from a quiescent vasculature to an actively growing one follows a series of synchronic events and is finely tuned by a wide array of molecules and positive and negative regulators of angiogenesis. Beginning with blood vessel sprouting and endothelial cell proliferation, followed by vessel navigation, remodeling, stabilization, and maturation, and finishing with blood vessel regression, the main molecular factors involved in the progression of each step are profoundly detailed. When the balance between positive and negative regulators of angiogenesis is shifted toward proangiogenic molecules, the quiescent vasculature becomes activated and initiates the angiogenic state of tumor development. The role of intratumoral hypoxia as a potent activator of the angiogenic switch, its regulation and a detailed description of normal and aberrant tumor vessels are also provided. The understanding of the foundations of these mechanisms is crucial for an effective therapeutic targeting of the angiogenic process.

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  1. Tumor Angiogenesis Group, ProCURE, Catalan Institute of Oncology-IDIBELL, 08908, Barcelona, Spain

    Iratxe Zuazo-Gaztelu & Oriol Casanovas

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  1. Iratxe Zuazo-Gaztelu
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  2. Oriol Casanovas
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  1. Tumor Biology Center, Freiburg, Baden-Württemberg, Germany

    Dieter Marmé

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Zuazo-Gaztelu, I., Casanovas, O. (2016). Mechanisms of Tumor Angiogenesis. In: Marmé, D. (eds) Tumor Angiogenesis. Springer, Cham. https://doi.org/10.1007/978-3-319-31215-6_1-1

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