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Handbook of Nutrition, Diet, and Epigenetics pp 1–21Cite as

Epigenetic Targeting of Vascular Endothelial Growth Factor (VEGF) Receptors

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Abstract

Signaling through VEGF receptors is not limited to the regulation of angiogenesis. Emerging data now links VEGF as a critical survival factor in carcinogenesis, with additional roles in immune surveillance and cancer stem cells. While a significant effort has been made within the pharmaceutical space to directly target VEGF signaling, results have been mixed. Research has shown that both VEGF and its associated receptors are epigenetically regulated and as such may be targetable through agents that inhibit the epigenetic regulatory machinery.

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Abbreviations

BET:

Bromodomain and extra-terminal domain

BRD:

Bromodomain-containing protein

DCR:

Disease control rate

EZH2:

Enhancer of zeste, drosophila, homolog 2

HDAC:

Histone deacetylase

KAT:

Lysine-specific acetyltransferase

KDM:

Lysine-specific demethylase

KMT:

Lysine-specific methyltransferase

NGS:

Next-generation sequencing

ORR:

Objective response rate

OS:

Overall survival

PFS:

Progression-free survival

PRC2:

Polycomb repressive complex 2

PTM:

Posttranslational modification

VEGF:

Vascular endothelial growth factor

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  1. Thoracic Oncology Research Group, Trinity Translational Medical Institute, St James’s Hospital, Rm 2.09, D08 W9RT, Dublin, Ireland

    Steven G. Gray

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  1. Steven G. Gray
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Correspondence to Steven G. Gray .

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  1. c/o Editorial Board 978-0-387-78665 , Heidelberg, Baden-Württemberg, Germany

    Vinood Patel

  2. Kings College , London, United Kingdom

    Victor Preedy

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Gray, S.G. (2017). Epigenetic Targeting of Vascular Endothelial Growth Factor (VEGF) Receptors. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_36-1

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  • DOI: https://doi.org/10.1007/978-3-319-31143-2_36-1

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  • Print ISBN: 978-3-319-31143-2

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