Abstract
Epigenetics is a mechanism that can change gene expression, not by changing the genomic sequence but by changing epigenomic modifications such as DNA methylation and histone acetylation. Failure of epigenetic mechanisms results in various congenital neurodevelopmental disorders, suggesting that these mechanisms are essential for normal brain development. Epigenetic mechanisms are affected by various environmental factors including nutrients such as folic acid and various histone deacetylase inhibitors during early life. Since these nutrients are essential for epigenetic modifications, their insufficient intake in the early developmental period can induce epigenomic abnormalities that lead to dysregulation of gene expression in the brain, which may result in acquired neurodevelopmental and mental disorders. Therefore, on the basis of the epigenetic understanding of the effects of nutrients, early intervention with an appropriate therapy and education in nursery and preschools is important to prevent or ameliorate acquired neurodevelopmental and mental disorders.
Abbreviations
- AHRR:
-
Aryl hydrocarbon receptor
- ARA:
-
Arachidonic acid
- DHA:
-
Docosahexaenoic acid
- DNMT:
-
DNA methyltransferase
- DOHaD:
-
Developmental origins of health and disease
- Gr:
-
Glucocorticoid receptor
- HDACi:
-
Histone deacetylase inhibitor
- iPSC:
-
Induced pluripotent stem cell
- MBD:
-
Methyl-CpG binding domain
- MYO1G:
-
Myosin 1g
- PPAR:
-
Peroxisome proliferator-activated receptor
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Kubota, T., Mochizuki, K. (2017). Epigenetic Effects of Nutrients Involved in Neurodevelopmental and Mental Disorders. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_10-1
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