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Ions and Fluid Dynamics in Hypertension

  • Avram Z. TraumEmail author
Reference work entry

Abstract

Ion transport is known to be involved in the genesis of hypertension and is utilized therapeutically. However, the mechanisms behind sodium flux that may lead to hypertension are not well understood. Target proteins of diuretic agents, monogenic forms of hypertension, and genetic disorders of renal salt wasting have all provided insight into these pathways. In this chapter, we review some of these channels and their relevance to human hypertension. We explore the role of the cytoskeletal protein adducin in the regulation of sodium transport. We examine the function of the osmotically inactive sodium compartment and its regulation, and hormonal alterations affecting this compartment in salt-sensitive hypertension.

Keywords

Sodium channel Salt sensitive Adducin Ouabain Rostafuroxin Osmotically active sodium 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of NephrologyBoston Children’s HospitalBostonUSA
  2. 2.Department of PediatricsHarvard Medical SchoolBostonUSA

Section editors and affiliations

  • Julie R. Ingelfinger
    • 1
  1. 1.Pediatric Nephrology UnitMassGeneral Hospital for Children at MGH, Harvard Medical SchoolBostonUSA

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