Neonatology pp 669-674 | Cite as

Micronutrients and Vitamins

  • Olivier Claris
  • Guy Putet
Reference work entry


Vitamins and micronutrients are essential for many cellular processes, but excessive intake may also be toxic. Iron, zinc, and copper compete for intestinal absorption. The first sign of iron deficiency is anemia, while an excessive intake may cause oxidative stress and may also impact on cardiac and liver function. Zinc deficiency may cause growth arrest, irritability, anorexia, alopecia, esophagitis, and diarrhea. Copper deficiency is associated with hypochromic anemia, hypotonia, failure to grow, diarrhea, bone abnormalities, and neutropenia. Iodine deficiency may impair growth and intellectual performance. Thiamin deficiency is known as “beriberi,” while Niacin deficiency is known as pellagra. This chapter summarizes the most recent recommendations for vitamin and micronutrient intake.


  1. Aggett PJ, Haschke F, Heine W et al (1991) Comment on the content and composition of lipids in infant formulas. ESPGAN Committee on Nutrition. Acta Paediatr Scand 80:887–896CrossRefGoogle Scholar
  2. Agostini C, Buonocore G, Carnielli VP et al (2010) Enteral supply for preterm infants. A comment of the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 50:1–9CrossRefGoogle Scholar
  3. Franz AR, Mihatsch WA, Sander S et al (2000) Prospective randomized trial of early versus late enteral iron supplementation in infants with a birth weight of less than 1301 grams. Pediatrics 106:700–706CrossRefGoogle Scholar
  4. Friel JK, Penneys S, Reid DW, Andrews WL (1988) Zinc, copper, manganese, and iron balance of parenterally fed VLBW preterm infants receiving a trace element supplement. J Parenter Enter Nutr 12:382–386CrossRefGoogle Scholar
  5. Greer FR (2005) Vit A, E and K. In: Tsang RC, Uauy R, Koletzko B, Zlotkin SH (eds) Nutrition of the preterm infant. Scientific basis and practical application, 2nd edn. Digital Educational Publishing, Cincinnati, pp 141–172Google Scholar
  6. Koletzko B, Goulet O, Hunt J et al (2005a) Iron, mineral and trace elements. J Pediatr Gastroenterol Nutr 41:S39–S46CrossRefGoogle Scholar
  7. Koletzko B, Goulet O, Hunt J et al (2005b) Vitamines. J Pediatr Gastroenterol Nutr 41:S47–S53CrossRefGoogle Scholar
  8. Lucas A, Bates C (1984) Transient riboflavin depletion in preterm infants. Arch Dis Child 59:837–841CrossRefGoogle Scholar
  9. Raju TNK, Langenberg P, Bhutani V, Quinn GE (1997) Vitamin E prophylaxis to reduce retinopathy of prematurity: a reappraisal of published trials. J Pediatr 131:844–850CrossRefGoogle Scholar
  10. Rogahn J, Ryan S, Wells J et al (2000) Randomised trial of iodine intake an thyroid status in preterm infants. Arch Dis Child Fetal Neonatal Ed 83:F86–F90CrossRefGoogle Scholar
  11. Salle B, David L, Glorieux FH et al (1982) Early oral administration of vitamin D and its metabolites in premature neonates. Effects on mineral homeostasis. Pediatr Res 16:75–78CrossRefGoogle Scholar
  12. Tsang RC, Uauy R, Koletzko B, Zlotkin SH (eds) (2005) Nutrition of the preterm infant. Scientific basis and practical application, 2nd edn. Digital Educational Publishing, CincinnatiGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Olivier Claris
    • 1
    • 2
  • Guy Putet
    • 3
  1. 1.Department of NeonatologyHôpital Femme Mère EnfantBronFrance
  2. 2.Hospices Civils de Lyon and Université Claude BernardLyonFrance
  3. 3.Department of NeonatologyHopital de la Croix-Rousse, Hospices Civils de Lyon and Universite Claude BernardLyonFrance

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