Definition
A chronic, benign, self-limiting lesion, commonly presenting as an ulceration with elevated margins on the lateral or ventral surface of the tongue of unknown etiology. It develops rapidly and usually persists for several weeks or months. It may mimic oral cancer. Due to a history of traumatic injury in about one third of the cases, a traumatic cause has been suggested. However, metachronous and multiple synchronous lesions at different sites argue for the fact that other factors than trauma must be involved.
Clinical Features
Incidence
Unknown, probably relatively common.
Age
All ages, most commonly in children and young adults. In children, the lesion has been called Riga-Fede’s disease.
Sex
Equal sex distribution. In some series, a male, in others, a female...
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References and Further Reading
El-Mofty, S. K., Swanson, P. E., Wick, M. R., & Miller, A. S. (1993). Eosinophilic ulcer of the oral mucosa. Report of 38 new cases with immunohistochemical observations. Oral Surgery, Oral Medicine, and Oral Pathology, 75, 716–722.
Elzay, R. P. (1983). Traumatic ulcerative granuloma with stromal eosinophilia (Riga-Fede’s disease and traumatic eosinophilic granuloma). Oral Surgery, Oral Medicine, and Oral Pathology, 55, 497–506.
Hirshberg, A., Amariglio, N., Akrish, S., Yahalom, R., Rosenbaum, H., Okon, E., & Kaplan, I. (2006). Traumatic ulcerative granuloma with stromal eosinophilia. A reactive lesion of the oral mucosa. American Journal of Clinical Pathology, 126, 522–529.
Sarangarajan, R., Vaishanavi Vedam, V. K., Sivadas, G., Sarangarajan, A., & Meera, S. (2015). Traumatic ulcerative granuloma with stromal eosinophilia – Mystery of pathogenesis revisited. Journal of Pharmacy & Bioallied Sciences, 7(Suppl 2), S420–S423.
Segura, S., & Pujol, R. M. (2008). Eosinophilic ulcer of the oral mucosa: A distinct entity or a non-specific reactive pattern. Oral Diseases, 14, 287–295.
Segura, S., Romero, D., Mascaro, J. M., Colomo, L., Ferrando, J., & Estrach, T. (2006). Eosinophilic ulcer of the oral mucosa: Another histological simulator of CD30+ lymphoproliferative disorders. British Journal of Dermatology, 155, 460–463.
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van der Wal, J.E. (2017). Eosinophilic Ulcer. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_696-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_696-1
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Publisher Name: Springer, Cham
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