Cheilitis granulomatosa, first described by Miescher in 1945, is together with Melkersson–Rosenthal syndrome subsets of orofacial granulomatosis. Clinically, patients present with a nontender, persistent swelling of one or both lips. The labial swelling may be associated with orofacial swelling affecting the chin, eyelids, cheeks, gingiva, and oral mucosa.
It is estimated that the incidence is 0.08% in the population.
Mostly adults, although it can occur in childhood. In children and adults under 30 years of age, an association with an asymptomatic, non-Crohn’s disease, gastrointestinal inflammatory process, or food allergy has been shown.
Cheilitis granulomatosa has a female predilection.
Upper and lower lip.
First, try to find the underlying cause by thorough clinical examination. Individual lesions have been treated with several different interventions as topical or intralesional corticosteroids, triamcinolone, radiotherapy, sulfasalazine, hydroxychloroquine sulfate, azathioprine, cyclosporine A, methotrexate, antibiotics, and others. Spontaneous remissions have been published as well.
The prognosis is highly variable. It is a recurrent disease and may be episodic and intermittent. No therapy has been proven to be of benefit in every patient.
Melkersson–Rosenthal syndrome, with fissured tongue and facial paralysis.
Allergic reaction to several agents.