Definition
Cheilitis granulomatosa, first described by Miescher in 1945, is together with Melkersson–Rosenthal syndrome subsets of orofacial granulomatosis. Clinically, patients present with a nontender, persistent swelling of one or both lips. The labial swelling may be associated with orofacial swelling affecting the chin, eyelids, cheeks, gingiva, and oral mucosa.
Clinical Features
Incidence
It is estimated that the incidence is 0.08% in the population.
Age
Mostly adults, although it can occur in childhood. In children and adults under 30 years of age, an association with an asymptomatic, non-Crohn’s disease, gastrointestinal inflammatory process, or food allergy has been shown.
Sex
Cheilitis granulomatosa has a female predilection.
Site
Upper and lower lip.
Treatment
First, try to find the underlying cause by thorough clinical examination. Individual lesions have been treated with several different...
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References and Further Reading
Critchlow, W. A., & Chang, D. (2014). Cheilitis granulomatosa: A review. Head and Neck Pathology, 8, 209–213.
El-Hakim, M., & Chauvin, P. (2004). Orofacial granulomatosis presenting as persistent lip swelling: Review of 6 new cases. Journal of Oral and Maxillofacial Surgery, 62, 1114–1117.
Kaminagakura, E., & Jorge, J., Jr. (2011). Melkersson–Rosenthal syndrome: A histopathologic mystery and dermatologic challenge. Journal of Cutaneous Pathology, 38, 241–245.
van der Waal, R. I. F., Schulten, E. A. J. M., van der Scheur, M. R., Wauters, I. M. P. M. J., Starink, T. M., & van der Waal, I. (2001). Cheilitis granulomatosa. Journal of the European Academy of Dermatology and Venereology, 15, 519–523.
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van der Wal, J.E. (2018). Cheilitis Granulomatosa. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_667-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_667-1
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Publisher Name: Springer, Cham
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