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Alcohol-related chronic pancreatitis (CP) is the most common subtype of chronic pancreatitis. Almost 50% of chronic pancreatitis cases are attributable to alcohol abuse (Majumder and Chari 2016). Commonly, this subtype becomes clinically apparent with recurrent acute pancreatitis (Braganza et al. 2011; Klöppel 2007; Pham and Forsmark 2018). Characteristically, intraductal protein plugs and calculi are observed (Braganza et al. 2011; Esposito et al. 2020; Steer et al. 1995). In advanced stages, the gland shows a diffuse fibrosis (Braganza et al. 2011; Esposito et al. 2020; Klöppel 2007). As a result of destruction of the exocrine and endocrine parenchyma, steatorrhea and diabetes mellitus type 3c develop (Esposito et al. 2020; Majumder and Chari 2016; Klöppel 2007; Steer et al. 1995). Moreover, pain, pseudocysts, bile duct obstructions, thrombosis, necrosis, and erosions of vessels are possible complications (Esposito et al. 2020;...
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References and Further Reading
Braganza, J. M., Lee, S. H., McClo, R. F., & McMahon, M. J. (2011). Chronic pancreatitis. Lancet, 377, 1184–1197.
Esposito, I., Hruban, R. H., Verbeke, C., Terris, B., Zamboni, G., Scarpa, A., Morohoshi, T., Suda, K., Luchini, C., Klimstra, D. S., Adsay, V., Haeberle, L., Saluja, A., Fernandez-Del Castillo, C., Sheel, A., Neoptolemos, J. P., Isaji, S., Shimosegawa, T., Whitcomb, D. C., Campbell, F., … Working group for the International (IAP – APA – JPS – EPC) Consensus Guidelines for Chronic Pancreatitis (2020). Guidelines on the histopathology of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and the European Pancreatic Club. Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et al.], 20(4), 586–593.
Kleeff, J., Whitcomb, D. C., Shimosegawa, T., Esposito, I., Lerch, M. M., Gress, T., Mayerle, J., Drewes, A. M., Rebours, V., Akisik, F., Muñoz, J., & Neoptolemos, J. P. (2017). Chronic pancreatitis. Nature Reviews Disease Primers, 3, 17060.
Klöppel, G. (2007). Chronic pancreatitis, pseudotumors and other tumor-like lesions. Modern Pathology, 20, S113–S131.
Majumder, S., & Chari, S. T. (2016). Chronic pancreatitis. Lancet, 387(10031), 1957–1966.
Pham, A., & Forsmark, C. (2018). Chronic pancreatitis: review and update of etiology, risk factors, and management. F1000Research, 7, F1000 Faculty Rev-607.
Steer, M. L., Waxman, I., & Freedman, S. (1995). Chronic pancreatitis. The New England Journal of Medicine, 332(22), 1482–1490.
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Kraft, A., Gaida, M.M. (2021). Alcohol-Related Chronic Pancreatitis. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5517-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5517-1
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