Synonyms
Definition
Annular pancreas is a rare congenital malformation consisting of pancreatic tissue forming a ring around the descending portion of the duodenum due to an incomplete rotation of the ventral pancreatic bud. Complete and incomplete annular pancreas exist.
Clinical Features
Incidence
Annular pancreas occurs in 1:12,000–15,000 of the general population (Hulvat et al. 2006).
The annual incidence is estimated at around 1/50,000 births, representing 10% of all cases of duodenal stenosis (Bargy 2019).
Age
Annular pancreas is a congenital condition. The mean age of diagnosis in children is 1 day. In children, annular pancreas is associated with trisomy 21 and other congenital diseases such as Meckel’s diverticulum, intestinal, or cardiac malformations. In adults, annular pancreas is mostly diagnosed in patients aged 30–60 years (mean age of diagnosis in adults: 47 years) (Zyromski et al. 2008), and it has been described in association with chronic...
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References and Further Reading
Bargy, F. (2019). Annular pancreas. Online verfügbar unter https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=675
Brönnimann, E., Potthast, S., Vlajnic, T., Oertli, D., & Heizmann, O. (2010). Annular pancreas associated with duodenal carcinoma. World Journal of Gastroenterology, 16(25), 3206–3210. https://doi.org/10.3748/wjg.v16.i25.3206.
Escobar, M. A., Ladd, A. P., Grosfeld, J. L., West, K. W., Rescorla, F. J., Scherer, L. R., et al. (2004). Duodenal atresia and stenosis: Long-term follow-up over 30 years. Journal of Pediatric Surgery, 39(6), 867–871; discussion 867–71. https://doi.org/10.1016/j.jpedsurg.2004.02.025.
Hulvat, M. C., Kumar, R. B., Newman, B. M., & Muraskas, J. K. (2006). Annular pancreas in identical twin newborns. Journal of Pediatric Surgery, 41(8), e19–e21. https://doi.org/10.1016/j.jpedsurg.2006.04.028.
Jarikji, Z., Horb, L. D., Shariff, F., Mandato, C. A., Cho, K. W. Y., & Horb, M. E. (2009). The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds. Development (Cambridge, England), 136(11), 1791–1800. https://doi.org/10.1242/dev.032235.
Zyromski, N. J., Sandoval, J. A., Pitt, H. A., Ladd, A. P., Fogel, E. L., Mattar, W. E., et al. (2008). Annular pancreas: Dramatic differences between children and adults. Journal of the American College of Surgeons, 206(5), 1019–1025; discussion 1025–7. https://doi.org/10.1016/j.jamcollsurg.2007.12.009.
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Ingenhoff, L. (2020). Annular Pancreas. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5503-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5503-1
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