Eosinophilic Solid and Cystic Renal Cell Carcinoma

Definition

Eosinophilic solid and cystic renal cell carcinoma is a recently described tumor arising in patient with and without tuberous sclerosis characterized by cells with eosinophilic cytoplasm and varying solid and cystic architectural growth (Trpkov et al. 2016).

Clinical Features

• Incidence

  The tumor is extremely rare, comprising less than 1% of all renal carcinomas.

• Age

  The tumor typically occurs in adults. However it has been described in young patients (less than 35 years of age).

• Sex

  The majority of tumors that have been reported occurred in females.

• Site

  There is no site predilection.

• Treatment

  Partial or radical nephrectomy is the standard of treatment.

• Outcome

  The clinical behavior is indolent.

Macroscopy

Grossly, the tumors are well-delineated, tan masses, typically showing solid and macrocystic architecture. In some cases there is a dominant cystic appearance.

Microscopy

Eosinophilic solid and cystic renal cell carcinoma shows solid and micro- and/or macrocystic...